Methyl 2-(4-methylphenylsulfonamido)acetate

Base Information

• Chemical Name: Methyl 2-(4-methylphenylsulfonamido)acetate
• CAS No.: 2645-02-5
• Molecular Formula: C10H13NO4S
• Molecular Weight: 243.284
• Hs Code.: 2935009090
• Mol file: 2645-02-5.mol

Synonyms:Glycine,N-(p-tolylsulfonyl)-, methyl ester (6CI,7CI,8CI);Methyl (tosylamino)acetate;Methyl N-[(4-methylphenyl)sulfonyl]glycinate;N-Tosylglycine methyl ester;

Chemical Property of Methyl 2-(4-methylphenylsulfonamido)acetate

Chemical Property:

• Melting Point: 89-91 °C
• Boiling Point: 372.5 °C at 760 mmHg
• PKA: 9.09±0.50(Predicted)
• Flash Point: 179.1 °C
• PSA: 80.85000
• Density: 1.261 g/cm³
• LogP: 1.91800
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-(4-methylphenylsulfonamido)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(4-methylphenylsulfonamido)acetate

There total 16 articles about Methyl 2-(4-methylphenylsulfonamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-Tosylglycine (1080-44-0) → methyl tosylglycinate (2645-02-5)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1021/acs.orglett.9b00005

Reference yield: 98.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + p-toluenesulfonyl chloride (98-59-9) → methyl tosylglycinate (2645-02-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ol052529c

Reference yield: 90.0%

N-Tosylglycine (1080-44-0) + methyl 1-imidazolecarboxylate (61985-23-7) → methyl tosylglycinate (2645-02-5)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol1018882

upstream raw materials:

methanol

N-Tosylglycine

glycine ethyl ester hydrochloride

p-toluenesulfonyl chloride

Downstream raw materials:

p-toluenesulfonylglycine isopropyl ester

α-methoxy-N-(4-toluenesulphonyl)-glycine methyl ester

(toluene-4-sulfonylimino)-di-acetic acid dimethyl ester

N-(o-methylbenzyl)-N-(p-toluenesulfonyl)glycine methyl ester

Refernces

• 1、 Cheng, Xionglve,Jiang, Gangzhong,Li, Xingxing,Tao, Suyan,Wan, Xiaobing,Zhao, Yanwei,Zheng, Yonggao. "Green Esterification of Carboxylic Acids Promoted by tert-Butyl Nitrite". supporting information. p. 2713 - 2718. Retrieved 2021/06/25.
• 2、 Engl, Sebastian,Reiser, Oliver. "Catalyst-Free Visible-Light-Mediated Iodoamination of Olefins and Synthetic Applications". supporting information. p. 5581 - 5586. Retrieved 2021/07/26.