2-Pyrimidinecarboxaldehyde

Base Information

• Chemical Name: 2-Pyrimidinecarboxaldehyde
• CAS No.: 27427-92-5
• Molecular Formula: C5H4N2O
• Molecular Weight: 108.1
• Hs Code.: 29335990
• Mol file: 27427-92-5.mol

Synonyms:PYRIMIDINE-2-CARBALDEHYDE;pyrimidine-2-aldehyde;2-Pyrimidinecarboxaldehyde;2-formylpyrimidine;2-Pyrimidinecarboxaldehyde (8CI,9CI);2-Pyrimidinecarbaldehyde;Pyrimidine-2-carboxaldehyde;REF DUPL: 2-Pyrimidinecarboxaldehyde

Chemical Property of 2-Pyrimidinecarboxaldehyde

Chemical Property:

• Boiling Point: 267.441 °C at 760 mmHg
• PKA: -1.13±0.13(Predicted)
• Flash Point: 119.554 °C
• PSA: 42.85000
• Density: 1.235 g/cm³
• LogP: 0.28910

Purity/Quality:

98% ^*data from raw suppliers

2-Pyrimidinecarboxaldehyde >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinecarboxaldehyde

There total 5 articles about 2-Pyrimidinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-pyrimidinemethanol (42839-09-8) → pyrimidine-2-carbaldehyde (27427-92-5)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 60 - 110 ℃; for 4h;

DOI:10.1039/d0nj02056g

Reference yield:

pyrimidine-2-carboxylic acid methyl ester (34253-03-7) → pyrimidine-2-carbaldehyde (27427-92-5)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -70 ℃; for 1h;

DOI:10.1002/ejoc.200500058

Reference yield:

2-cyanopyrimidine (14080-23-0) → pyrimidine-2-carbaldehyde (27427-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / HCl / methanol / 2 h / Heating

2: DIBAL / hexane; CH₂Cl₂ / 1 h / -70 °C

With hydrogenchloride; diisobutylaluminium hydride; In methanol; hexane; dichloromethane;

DOI:10.1002/ejoc.200500058

upstream raw materials:

pyrimidine-2-carboxylic acid methyl ester

2-cyanopyrimidine

pyrimidine-2-carboxylic acid

2-pyrimidinemethanol

Downstream raw materials:

ethyl (E)-3-(pyrimidin-2-yl)propenoate

ethyl (E)-3-(1-oxidopyrimidin-2-yl)propenoate

(S)-2-methylpropane-2-sulfinic acid 1-pyrimidin-2-ylmethylideneamide

1-phenyl-1-(2-pyrimidinyl)methanol

Refernces

• 1、 Zeng, Peng,Zheng, Ya,Chen, Shengtao,Liu, Haoran,Li, Renjie,Peng, Tianyou. "Asymmetric zinc porphyrin derivatives bearing three pseudo-pyrimidine: Meso -position substituents and their photosensitization for H2evolution". . p. 11237 - 11247. Retrieved 2020.
• 2、 -. "Synthesizing process of nitrogen-heterocyclic high-selectivity aldehyde". Paragraph 0014; 0022; 0023; 0035; 0041; 0048; 0054. . Retrieved 2017/09/05.