ethyl (E)-3-(pyrimidin-2-yl)propenoate

Base Information

• Chemical Name: ethyl (E)-3-(pyrimidin-2-yl)propenoate
• CAS No.: 865692-66-6
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.191
• Mol file: 865692-66-6.mol

Synonyms:ethyl (E)-3-(pyrimidin-2-yl)propenoate

Chemical Property of ethyl (E)-3-(pyrimidin-2-yl)propenoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

(E)-Ethyl3-(pyrimidin-2-yl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (E)-3-(pyrimidin-2-yl)propenoate

There total 5 articles about ethyl (E)-3-(pyrimidin-2-yl)propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + pyrimidine-2-carbaldehyde (27427-92-5) → ethyl (E)-3-(pyrimidin-2-yl)propenoate (865692-66-6)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h;

pyrimidine-2-carbaldehyde; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

Reference yield: 65.0%

PYRIMIDINE (289-95-2,25247-63-6) + ethyl acrylate (140-88-5,9003-32-1) → ethyl (E)-3-(pyrimidin-2-yl)propenoate (865692-66-6)

Guidance literature:

With 2-hydroxy-5-methyl-3-nitropyridine; palladium diacetate; fluorescein free acid; at 30 - 35 ℃; for 28h; regioselective reaction; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c12311

Reference yield:

pyrimidine-2-carbaldehyde (27427-92-5) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl (E)-3-(pyrimidin-2-yl)propenoate (865692-66-6)

Guidance literature:

In hexane; dichloromethane; at -70 - 20 ℃; for 1h;

DOI:10.1002/ejoc.200500058

upstream raw materials:

pyrimidine-2-carbaldehyde

ethyl (triphenylphosphoranylidene)acetate

2-cyanopyrimidine

pyrimidine-2-carboxylic acid methyl ester

Refernces

• 1、 -. "DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF". Paragraph 0378-0380. . Retrieved 2020/12/13.
• 2、 -. "INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF". Page/Page column 80; 81. . Retrieved 2018/04/13.