2-AMINO-3-NITRO-5-FLUOROPYRIDINE

Base Information

• Chemical Name: 2-AMINO-3-NITRO-5-FLUOROPYRIDINE
• CAS No.: 212268-12-7
• Molecular Formula: C5H4FN3O2
• Molecular Weight: 157.104
• Hs Code.: 2933399090
• Mol file: 212268-12-7.mol

Synonyms:2-Amino-3-nitro-5-fluoropyridine;2-Amino-5-fluoro-3-nitropyridine;5-Fluoro-3-nitro-2-aminopyridine;2-amino-5-fluoro-3-nitropyridine;5-fluoro-3-nitropyridine-2-amine;

Chemical Property of 2-AMINO-3-NITRO-5-FLUOROPYRIDINE

Chemical Property:

• Vapor Pressure: 0.00211mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 290.1 °C at 760 mmHg
• PKA: 0.12±0.49(Predicted)
• Flash Point: 129.3 °C
• PSA: 84.73000
• Density: 1.555 g/cm³
• LogP: 1.81550
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-nitro-5-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-NITRO-5-FLUOROPYRIDINE

There total 4 articles about 2-AMINO-3-NITRO-5-FLUOROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.6%

2-amino-5-fluoropyridine (21717-96-4) → 2-amino-5-fluoro-3-nitropyridine (212268-12-7)

Guidance literature:

With nitric acid; In methanol; diethyl ether; dichloromethane; sulfuric acid; Petroleum ether;

Reference yield:

2-chloro-5-fluoro-3-nitro pyridine (136888-21-6) → 2-amino-5-fluoro-3-nitropyridine (212268-12-7)

Guidance literature:

With sodium azide; copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; L-proline; In water; dimethyl sulfoxide; at 70 ℃; for 24h;

Reference yield:

2,3-dichloro -5-fluoropyridine (185985-40-4) → 2-amino-5-fluoro-3-nitropyridine (212268-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / 24 h / 180 °C

2: potassium carbonate; ethylenediaminetetraacetic acid; dihydrogen peroxide / acetonitrile; water / 1 h / 20 °C

3: sodium azide; sodium L-ascorbate; copper(ll) sulfate pentahydrate; L-proline; sodium carbonate / water; dimethyl sulfoxide / 24 h / 70 °C

With ammonium hydroxide; sodium azide; copper(ll) sulfate pentahydrate; ethylenediaminetetraacetic acid; dihydrogen peroxide; sodium carbonate; potassium carbonate; sodium L-ascorbate; L-proline; In water; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

2-amino-5-fluoropyridine

2,3-dichloro -5-fluoropyridine

2-chloro-5-fluoro-3-nitropyridine

2-chloro-5-fluoro-3-nitro pyridine

Downstream raw materials:

5-fluoro-2,3-pyridinediamine

2-chloro-5-fluoro-3-nitro pyridine

2-amino-5-fluoropyridine

Refernces

• 1、 -. "Triazole methyl ester linked spiro compound with antibacterial activity, and preparation method and application thereof". . . Retrieved 2018/05/16.
• 2、 -. "Compounds for inhibition of gastric acid secretion". . . Retrieved 2008/06/13.