3-Amino-2-chloro-5-fluoropyridine

Base Information

• Chemical Name: 3-Amino-2-chloro-5-fluoropyridine
• CAS No.: 884495-37-8
• Molecular Formula: C5H4ClFN2
• Molecular Weight: 146.552
• Hs Code.: 2933399990
• Mol file: 884495-37-8.mol

Synonyms:2-chloro-5-fluoropyridin-3-amine

Chemical Property of 3-Amino-2-chloro-5-fluoropyridine

Chemical Property:

• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 249.7 °C at 760 mmHg
• PKA: 0.08±0.10(Predicted)
• Flash Point: 104.8 °C
• PSA: 38.91000
• Density: 1.449g/cm³
• LogP: 2.03750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-5-fluoropyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-2-chloro-5-fluoropyridine

There total 5 articles about 3-Amino-2-chloro-5-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-fluoropyridine-3-carboxamide (75302-64-6) → 2-chloro-5-fluoro-3-nitropyridine (884495-37-8)

Guidance literature:

With sodium hypochlorite; sodium hydroxide; In water; at 20 - 45 ℃;

Reference yield:

tert-butyl (2-chloro-5-fluoropyridin-3-yl)carbamate (1394899-03-6) → 2-chloro-5-fluoro-3-nitropyridine (884495-37-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 45 ℃; for 1h;

Reference yield:

2-chloro-5-fluoro-3-nitro pyridine (136888-21-6) → 2-chloro-5-fluoro-3-nitropyridine (884495-37-8)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 5h; Reflux;

upstream raw materials:

2-chloro-5-fluoropyridine-3-carboxamide

2-chloro-5-fluoro-3-nitro pyridine

2-chloro-5-fluoronicotinic acid

tert-butyl (2-chloro-5-fluoropyridin-3-yl)carbamate

Downstream raw materials:

2,3-dichloro -5-fluoropyridine

2-amino-5-fluoro-3-nitropyridine

2-chloro-5-fluoro-3-nitro pyridine

2-amino-5-fluoropyridine

Refernces

• 1、 -. "Preparation method and application of novel spiro compound". Paragraph 0026; 0027. . Retrieved 2018/05/01.
• 2、 -. "HETEROBICYCLIC COMPOUNDS". . . Retrieved 2013/09/12.