N,N-dibenzyl-2-phenylacetamide

Base Information

• Chemical Name: N,N-dibenzyl-2-phenylacetamide
• CAS No.: 102459-18-7
• Molecular Formula: C₂₂H₂₁NO
• Molecular Weight: 315.415
• Mol file: 102459-18-7.mol

Synonyms:N,N-dibenzyl-2-phenylacetamide

Chemical Property of N,N-dibenzyl-2-phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dibenzyl-2-phenylacetamide

There total 19 articles about N,N-dibenzyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenylacetyl chloride (103-80-0) + dibenzylamine (103-49-1) → N,N-dibenzyl-2-phenylacetamide (102459-18-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/jacs.7b02983

Reference yield: 81.0%

phenylacetic acid (103-82-2) + dibenzylamine (103-49-1) → N,N-dibenzyl-2-phenylacetamide (102459-18-7)

Guidance literature:

With borane-ammonia complex; In 5,5-dimethyl-1,3-cyclohexadiene; for 12h; Reflux;

DOI:10.1021/acs.orglett.1c00591

Reference yield: 81.0%

N,N-dibenzyl-2-phenylethanethioamide (61821-54-3) → N,N-dibenzyl-2-phenylacetamide (102459-18-7)

Guidance literature:

With eosin; oxygen; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Irradiation; Green chemistry;

DOI:10.1039/c3nj00870c

upstream raw materials:

phenylacetyl chloride

dibenzylamine

1-Bromo-2-phenylacetylene

phenylacetylene

Downstream raw materials:

4-phenyl-1,4-dihydroisoquinolin-3(2H)-one

N,N-dibenzyl-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanamide

N,N-dibenzyl-N-(1-benzylcyclopropyl)amine

Refernces

• 1、 Ramachandran, P. Veeraraghavan,Hamann, Henry J.. "Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids". . p. 2938 - 2942. Retrieved 2021.
• 2、 Zhao, Feng,Shu, Chang,Young, Claire M.,Carpenter-Warren, Cameron,Slawin, Alexandra M. Z.,Smith, Andrew D.. "Enantioselective Synthesis of α-Aryl-β2-Amino-Esters by Cooperative Isothiourea and Br?nsted Acid Catalysis". supporting information. p. 11892 - 11900. Retrieved 2021/04/28.