2-Bromo-6-iodopyridine

Base Information

• Chemical Name: 2-Bromo-6-iodopyridine
• CAS No.: 234111-08-1
• Molecular Formula: C5H3BrIN
• Molecular Weight: 283.894
• Hs Code.: 29333990
• European Community (EC) Number: 640-666-5
• DSSTox Substance ID: DTXSID60462044
• Nikkaji Number: J1.108.539C
• Wikidata: Q72457615
• Mol file: 234111-08-1.mol

Synonyms:2-Bromo-6-iodopyridine;2-Iodo-6-bromopyridine;

Chemical Property of 2-Bromo-6-iodopyridine

Chemical Property:

• Vapor Pressure: 0.00448mmHg at 25°C
• Melting Point: 139-143℃
• Refractive Index: 1.665
• Boiling Point: 286.7 °C at 760 mmHg
• Flash Point: 127.2 °C
• PSA: 12.89000
• Density: 2.347g/cm³
• LogP: 2.44870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 282.84936
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-6-iodopyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)I)Br
• Uses: 6-trifluoromethyl-2-pyridinecarboxylic acid (4; 87%) was obtained from 2-bromo-6-(trifluoromethyl)pyridine, which was in turn derived from 2-bromo-6-iodopyridine by trifluoromethylating displacement of iodine.

Technology Process of 2-Bromo-6-iodopyridine

There total 7 articles about 2-Bromo-6-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-Dibromopyridine (626-05-1) → 2-iodo-6-bromopyridine (234111-08-1)

Guidance literature:

2,6-Dibromopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

With iodine; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(99)00789-3

Reference yield: 86.0%

2-bromo-pyridine (109-04-6) → 2-iodo-6-bromopyridine (234111-08-1)

Guidance literature:

2-bromo-pyridine; With lithium di-tert-butyl(2,2,6,6-tetramethylpiperidino)zincate; In diethyl ether; at 20 ℃;

With iodine; In diethyl ether; Further stages.;

DOI:10.1039/b108252n

Reference yield: 86.0%

C5NH3BrZn(C(CH3)3)2(1-)*Li(1+)=C5NH3BrZn(C(CH3)3)2Li + iodine (7553-56-2,12190-71-5,8031-47-8) → 2-iodo-6-bromopyridine (234111-08-1)

Guidance literature:

In diethyl ether; treatment with I2 in Et2O at room temp.;

DOI:10.1039/b108252n

upstream raw materials:

2,6-Dibromopyridine

2-bromo-pyridine

2-Amino-6-bromopyridine

iodine

Downstream raw materials:

2-bromo-6-(4-methoxyphenyl)pyridine

6'-bromo-5-(3-methoxy-phenyl)-[2,2']bipyridinyl

(6-bromopyridin-2-yl)(4’-methoxyphenyl)iodonium tosylate

(R)-5-(3-Amino-4-fluoro-1-(3-(6-(prop-1-ynyl)pyridin-2-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

Refernces

• 1、 Holmes, Brian T.,Pennington, William T.,Hanks. "Synthesis of "acetylene-expanded" tridentate ligands". . p. 447 - 455. Retrieved 2002.
• 2、 Chau, Nguyet Trang Thanh,Meyer, Maxime,Komagawa, Shinsuke,Chevallier, Floris,Fort, Yves,Uchiyama, Masanobu,Mongin, Florence,Gros, Philippe C.. "Homoleptic zincate-promoted room-temperature halogen-metal exchange of bromopyridines". experimental part. p. 12425 - 12433. Retrieved 2011/01/05.