cis-3,5-Dimethylpiperidine

Base Information

• Chemical Name: cis-3,5-Dimethylpiperidine
• CAS No.: 14446-75-4
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.203
• DSSTox Substance ID: DTXSID201296272
• Nikkaji Number: J150.566A
• Wikidata: Q40838086
• Mol file: 14446-75-4.mol

Synonyms:cis-3,5-Dimethylpiperidine;14446-75-4;cis-3,5-Dimethyl-piperidine;(3R,5S)-3,5-dimethylpiperidine;Piperidine, 3,5-dimethyl-, (3R,5S)-rel-;(3R,5S)-rel-3,5-Dimethylpiperidine;rel-(3R,5S)-3,5-dimethylpiperidine;MFCD09832871;cis-3,5-Lupetidine;3,5-Lupetidine, cis-;3,5-cis-dimethylpiperidine;SCHEMBL89457;3,5-dimethylpiperidine (cis);DTXSID201296272;(3S,5R)-3,5-dimethylpiperidine;Piperidine, 3,5-dimethyl-, cis-;1400908-06-6;AKOS006346052;piperidine, 3,5-dimethyl-, (3R,5S)-;CS-0139658;F12546;EN300-2009872;Q40838086

Chemical Property of cis-3,5-Dimethylpiperidine

Chemical Property:

• Boiling Point: 141.2±8.0 °C(Predicted)
• PKA: 10.52±0.10(Predicted)
• PSA: 12.03000
• Density: 0.794±0.06 g/cm3(Predicted)
• LogP: 1.58070
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 62.8

Purity/Quality:

99%, ^*data from raw suppliers

cis-3,5-Dimethylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC(CNC1)C
• Isomeric SMILES: C[C@@H]1C[C@@H](CNC1)C
• Uses: cis-3,5-Dimethylpiperidine is a useful reagent for preparing demulsifying agents for heavy crude oils.

Technology Process of cis-3,5-Dimethylpiperidine

There total 8 articles about cis-3,5-Dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-Lutidine (591-22-0) → (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7)

Guidance literature:

3,5-Lutidine; With potassium carbonate; at 150 ℃; for 5h; under 67506.8 Torr; Autoclave; Inert atmosphere;

In ethanol; hexane; at -10 - 20 ℃; for 1h; Reagent/catalyst; Autoclave; Inert atmosphere;

Reference yield:

cis-1-benzyl-3,5-dimethylpiperidine → (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 24h; under 5171.62 Torr;

Reference yield:

3,5-Lutidine (591-22-0) + methanol (67-56-1) → (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7) + 1,3,5-trimethylpiperidine (27644-32-2)

Guidance literature:

With hydrogen; In cyclohexane; at 190 ℃; for 396h; under 37503.8 Torr;

upstream raw materials:

3,5-Lutidine

3,5-dimethylpiperidine

methanol

Downstream raw materials:

cis-4-((3,5-dimethylpiperidin-1-yl)sulfonyl)benzoic acid

4-(3-(3,5-cis-dimethylpiperidin-1-yl)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-oxopropyl)benzoic acid, sodium salt

4-(3-(3,5-cis-dimethlpiperidin-1-yl)-3-oxo-1-(2,4,6-trimethoxyphenyl)-propyl)benzoic acid

Refernces

• 1、 -. "NEW 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS". Page/Page column 91; 92. . Retrieved 2018/07/05.
• 2、 -. "Modifications of mycinose and 3-O-demethylmycinose in tylosin-type macrolides". . . Retrieved 2008/06/13.