4-(Benzyloxy)benzohydrazide

Base Information

• Chemical Name: 4-(Benzyloxy)benzohydrazide
• CAS No.: 128958-65-6
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Hs Code.: 2928000090
• European Community (EC) Number: 630-214-5
• DSSTox Substance ID: DTXSID70364121
• Nikkaji Number: J1.742.738E
• Wikidata: Q82147900
• ChEMBL ID: CHEMBL1164663
• Mol file: 128958-65-6.mol

Synonyms:4-(benzyloxy)benzohydrazide;128958-65-6;4-BENZYLOXYBENZHYDRAZIDE;4-phenylmethoxybenzohydrazide;4-Benzyloxybenzohydrazide;4-(Benzyloxy)benzhydrazide;Benzoic acid, 4-(phenylmethoxy)-, hydrazide;CHEMBL1164663;4-benzyloxybenzoic acid hydrazide;Mono-2-octylphthalate;SCHEMBL863916;(4-benzyloxy benzoyl) hydrazine;4-(Benzyl-oxy)-benzoyl-hydrazin;DTXSID70364121;BBL003490;BDBM50320732;MFCD00564772;STK119329;AKOS000319457;AC-7818;FS-4327;CS-0204464;FT-0600999;EN300-14194;A805884;SR-01000074004;J-005639;SR-01000074004-1;Z58982727

Chemical Property of 4-(Benzyloxy)benzohydrazide

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 140 °C
• Refractive Index: 1.61
• PKA: 12?+-.0.10(Predicted)
• PSA: 64.35000
• Density: 1.201 g/cm³
• LogP: 2.96030
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 257

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzyloxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)C(=O)NN

Technology Process of 4-(Benzyloxy)benzohydrazide

There total 12 articles about 4-(Benzyloxy)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-benzyloxy-benzoic acid methyl ester (32122-11-5) → 4-benzyloxyphenylhydrazide (128958-65-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1016/S0968-0896(02)00611-9

Reference yield: 74.0%

ethyl 4-(benzyloxy)benzoate (56441-55-5) → 4-benzyloxyphenylhydrazide (128958-65-6)

Guidance literature:

With hydrazine hydrate; In propan-1-ol; for 48h; Heating;

DOI:10.1021/jm00061a006

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-benzyloxyphenylhydrazide (128958-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / acetone / 2 h / Heating

2: 97 percent / hydrazine hydrate / ethanol / 5 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/S0968-0896(02)00611-9

upstream raw materials:

ethyl 4-(benzyloxy)benzoate

4-benzyloxy-benzoic acid methyl ester

benzyl bromide

methyl 4-hydroxylbenzoate

Downstream raw materials:

bis[N-4-ethylbenzylidene(4-benzyloxy)benzoylhydrazinato]nickel(II)

potassium benzyloxybenzoyldithiocarbazate

3-benzyloxyphenyl-4-amino-5-mercapto-l,2,4-triazole

C₃₈H₂₆N₈O₂S₂

Refernces

• 1、 Nimbalkar, Urja D.,Tupe, Santosh G.,Vazquez, Julio A. Seijas,Khan, Firoz A. Kalam,Sangshetti, Jaiprakash N.,Nikalje, Anna Pratima G.. "Ultrasound- and molecular sieves-assisted synthesis, molecular docking and antifungal evaluation of 5-(4-(benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3h)-thiones". . . Retrieved 2016.
• 2、 Becker, Katja,Benvenuti, Manuela,Bossis, Guillaume,Conde, Pierre-Alexis,Crowder, Michael W.,Dillenberger, Melissa,Docquier, Jean-Denis,Gavara, Laurent,Hernandez, Jean-Fran?ois,Legru, Alice,Mangani, Stefano,Pozzi, Cecilia,Sannio, Filomena,Tassone, Giusy,Thomas, Caitlyn A.,Verdirosa, Federica. "1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity". supporting information. . Retrieved 2021/10/12.
• 3、 Shivakumar, Kilingaru I.,Pociecha, Damian,Szczytko, Jacek,Kapu?ciński, Szymon,Monobe, Hirosato,Kaszyński, Piotr. "Photoconductive bent-core liquid crystalline radicals with a paramagnetic polar switchable phase". supporting information. p. 1083 - 1088. Retrieved 2020/02/05.