tert-Butyl 2-(methylamino)ethylcarbamate

Base Information

• Chemical Name: tert-Butyl 2-(methylamino)ethylcarbamate
• CAS No.: 122734-32-1
• Molecular Formula: C8H18N2O2
• Molecular Weight: 174.243
• Hs Code.: 2924199090
• European Community (EC) Number: 805-762-5
• DSSTox Substance ID: DTXSID70392464
• Wikidata: Q72503591
• Mol file: 122734-32-1.mol

Synonyms:122734-32-1;tert-Butyl 2-(methylamino)ethylcarbamate;tert-Butyl (2-(methylamino)ethyl)carbamate;tert-butyl N-[2-(methylamino)ethyl]carbamate;1-(Boc-amino)-2-(methylamino)ethane;Boc-2-methylamino-ethylcarbamate;Tert-butyl (2-methylamino-ethyl)-carbamate;N-Boc-2-methylamino-ethylamine;MFCD06808585;N-Boc-N'-methylethylenediamine;tert-butyl(2-(methylamino)ethyl)carbamate;Carbamic acid, [2-(methylamino)ethyl]-, 1,1-dimethylethyl ester;tert-butyl [2-(methylamino)ethyl]carbamate;(2-Methylamino-ethyl)-carbamic acid tert-butyl ester;BocNHCH2CH2NHMe;Tert-butyl N-(2-methylaminoethyl)carbamate;boc-n-methylethylenediamine;SCHEMBL46654;AMY3806;DTXSID70392464;GKWGBMHXVRSFRT-UHFFFAOYSA-N;BBL101474;Carbamic acid, N-[2-(methylamino)ethyl]-, 1,1-dimethylethyl ester;N-Boc-N'-methyl-1,2-diaminoethane;STL555270;AKOS005259113;AC-2381;CS-W008686;SB32017;AS-19509;SY011917;tert-Butyl 2-(methylamino)(ethyl)carbamate;B4046;FT-0648125;EN300-64893;A26798;N-(tert-Butoxycarbonyl)-N'-methylethylenediamine;N-tert-butoxycarbonyl-2-(methylamino)-ethylamine;(2-Methylaminoethyl)carbamic acid tert-butyl ester;A804949;(2-methylamino-ethyl)carbamic acid tert-butyl ester;J-524411;N-(tert-butoxycarbonyl)-N'-(methyl)ethylenediamine;(2-methylamino ethyl)-carbamic acid tert-butyl ester;N-(2-Methylaminoethyl)carbamic Acid tert-Butyl Ester;N-(tert-Butoxycarbonyl)-N'-methyl-1,2-diaminoethane;tert-Butyl 2-(methylamino)ethylcarbamate, AldrichCPR;N-[2-(methylamino)ethyl]carbamic acid tert-butyl ester

Chemical Property of tert-Butyl 2-(methylamino)ethylcarbamate

Chemical Property:

• Vapor Pressure: 0.0125mmHg at 25°C
• Melting Point: 35 °C
• Refractive Index: 1.441
• Boiling Point: 260.1 °C at 760 mmHg
• PKA: 12?+-.0.46(Predicted)
• Flash Point: 111.1 °C
• PSA: 50.36000
• Density: 0.958 g/cm³
• LogP: 1.51230
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 174.136827821
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-(methylamino)ethylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCNC

Technology Process of tert-Butyl 2-(methylamino)ethylcarbamate

There total 18 articles about tert-Butyl 2-(methylamino)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C16H24N2O4 (1432971-80-6) → tert-butyl 2-(methylamino)ethylcarbamate (122734-32-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; for 2h;

Reference yield: 94.0%

[2-(benzylmethylamino)ethyl]carbamic acid tert-butyl ester (849472-99-7) → tert-butyl 2-(methylamino)ethylcarbamate (122734-32-1)

Guidance literature:

With hydrogen; 20% palladium hydroxide-activated charcoal; In methanol; water; for 2.5h;

Reference yield: 88.0%

C14H21N3O6S → tert-butyl 2-(methylamino)ethylcarbamate (122734-32-1)

Guidance literature:

With caesium carbonate; thiophenol; In N,N-dimethyl acetamide; at 20 ℃; for 16h;

upstream raw materials:

di-tert-butyl dicarbonate

N-methyl-ethane-1,2-diamine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

N-BOC-1,2-diaminoethane

Downstream raw materials:

(2-{[(2-tert-butoxycarbonylamino-ethyl)-methyl-amino]-methyl}-phenyl)-boronic acid

4-iodo-N-(2-methylaminoethyl)benzamide

4-bromo-2-fluoro-N-(2-dimethylaminoethyl)benzamide

(2-{[1-(3,4-Dichloro-benzyl)-piperidin-4-yl]-methyl-amino}-ethyl)-carbamic acid tert-butyl ester

Refernces

• 1、 -. "Preparation method of (2-methylamine-ethyl)-tert-butyl carbamate". Paragraph 0024-0029. . Retrieved 2019/07/01.
• 2、 -. "An enzyme and its optional [...] modified ketone and inhibitor composition comprising (by machine translation)". Paragraph 0364; 0377. . Retrieved 2017/01/23.