L-Methioninamide hydrochloride

Base Information

• Chemical Name: L-Methioninamide hydrochloride
• CAS No.: 16120-92-6
• Molecular Formula: C5H12N2OS^.HCl
• Molecular Weight: 184.69
• Hs Code.: 29309099
• European Community (EC) Number: 840-274-6
• ChEMBL ID: CHEMBL116966
• DSSTox Substance ID: DTXSID50594863
• Mol file: 16120-92-6.mol

Synonyms:16120-92-6;L-Methioninamide hydrochloride;H-MET-NH2 HCL;H-Met-NH2.HCl;(S)-2-Amino-4-(methylthio)butanamide hydrochloride;l-methioninamide hcl;L-Methionine amide hydrochloride;methioninamide hydrochloride;H-L-Met-NH2 Hydrochloride;L-Methioninamide (hydrochloride);MFCD00039084;(2S)-2-amino-4-methylsulfanylbutanamide;hydrochloride;Butanamide, 2-amino-4-(methylthio)-, hydrochloride (1:1), (2S)-;H-Met-NH HCl;H-Met-NH2 hydrochloride;methionine amide hydrochloride;CHEMBL116966;SCHEMBL1799491;(2S)-2-Amino-4-methylsulfanyl-butanamide hydrochloride;(S)-methioninamide hydrochloride;DTXSID50594863;PWCBMJHINDTXGV-WCCKRBBISA-N;Butanamide, 2-amino-4-(methylthio)-, monohydrochloride, (2S)-;AKOS015849590;AKOS015915936;CS-W016972;HY-W016256;AS-17595;BP-12486;L-Methioninamide--hydrogen chloride (1/1);M3402;EN300-206189;F10669;(S)-2-Amino-4-(methylthio)butanamidehydrochloride;J-009803;(2S)-2-amino-4-(methylsulfanyl)butanamide hydrochloride;(2S)-2-amino-4-(methylthio)-butanamide, monohydrochloride;2-Amino-4-methylsulfanyl-butyramide;compound with methane

Chemical Property of L-Methioninamide hydrochloride

Chemical Property:

• Vapor Pressure: 2.81E-05mmHg at 25°C
• Melting Point: 160-162 °C (decomp)(Solv: ethanol (64-17-5))
• Boiling Point: 351.8 °C at 760 mmHg
• Flash Point: 166.6 °C
• PSA: 94.41000
• LogP: 1.75470
• Storage Temp.: Store at RT.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 184.0437119
• Heavy Atom Count: 10
• Complexity: 97

Purity/Quality:

99% ^*data from raw suppliers

H-MET-NH2Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCCC(C(=O)N)N.Cl
• Isomeric SMILES: CSCC[C@@H](C(=O)N)N.Cl

Technology Process of L-Methioninamide hydrochloride

There total 4 articles about L-Methioninamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

s-methionine hydrochloride (6810-12-4) → (S)-methioninamide hydrochloride (16120-92-6)

Guidance literature:

With hexamethylphosphorous triamide dichloride; ammonia; In dichloromethane; 1) 30 min, -20 deg C, 2) 4 h, r.t.;

Reference yield:

(S)-N-(tert-butoxycarbonyl)methionine amide (34805-23-7) → (S)-methioninamide hydrochloride (16120-92-6)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1h; Ambient temperature;

DOI:10.1246/bcsj.65.3412

Reference yield:

N-tert-butoxycarbonyl-L-methionine (2488-15-5) → (S)-methioninamide hydrochloride (16120-92-6)

Guidance literature:

Multi-step reaction with 3 steps

2: NH₃

3: TFA / various solvent(s)

With ammonia; trifluoroacetic acid; In various solvent(s);

DOI:10.1016/S0960-894X(98)00642-8

upstream raw materials:

(S)-N-(tert-butoxycarbonyl)methionine amide

s-methionine hydrochloride

N-tert-butoxycarbonyl-L-methionine

C₁₅H₂₇NO₆S

Downstream raw materials:

{[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

benzyl N-((1S)-2-[(1S)-1-(aminocarbonyl)-3-(methylsulfanyl)propyl]amino-1-benzyl-2-oxoethyl)carbamate

N-Cbz-Ala

N-Cbz-L-Phe

Refernces

• 1、 Kaur,Patnaik,Raghubir,Chauhan. "Synthesis and biological evaluation of dehydrophenylalanine containing substance P fragments". . p. 3412 - 3418. Retrieved 2007/10/02.