Methionine hydrochloride

Base Information

• Chemical Name: Methionine hydrochloride
• CAS No.: 6810-12-4
• Molecular Formula: C5H12ClNO2S
• Molecular Weight: 185.67228
• Hs Code.: 2930909090
• UNII: 99JNR46OKX
• DSSTox Substance ID: DTXSID40431036
• Wikidata: Q27272218
• Mol file: 6810-12-4.mol

Synonyms:methionine hydrochloride;6810-12-4;l-methionine hydrochloride;L-Methionine, hydrochloride;99JNR46OKX;L-Methionine monohydrochloride;Methionine, L-, hydrochloride;L-Methionine, hydrochloride (1:1);(2S)-2-amino-4-methylsulfanylbutanoic acid;hydrochloride;(2S)-2-Amino-4-methylsulfanylbutanoic acid,hydrochloride;UNII-99JNR46OKX;SCHEMBL691801;DTXSID40431036;Methionine hydrochloride [WHO-DD];HY-W141867;CS-0201662;Q27272218

Chemical Property of Methionine hydrochloride

Chemical Property:

• PSA: 88.62000
• LogP: 1.65370
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 185.0277275
• Heavy Atom Count: 10
• Complexity: 97

Purity/Quality:

98%Min ^*data from raw suppliers

L-Methionine hydrochloride solution 100?mM amino acid in 0.1 M HCl, analytical standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CSCCC(C(=O)O)N.Cl
• Isomeric SMILES: CSCC[C@@H](C(=O)O)N.Cl

Technology Process of Methionine hydrochloride

There total 6 articles about Methionine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butoxycarbonyl-L-methionine (2488-15-5) → s-methionine hydrochloride (6810-12-4)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 1h; Sealed tube;

DOI:10.1039/d1ob00728a

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) → s-methionine hydrochloride (6810-12-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2016.09.001

Reference yield:

DL-methionine (59-51-8,26062-47-5,58576-49-1) → s-methionine hydrochloride (6810-12-4) + D-methionine hydrochloride (84228-57-9)

Guidance literature:

DL-methionine; With hydrogenchloride; In water; Heating / reflux; Resolution of racemate;

With poly-(N-methacryloyl-D-lysine); In water; at 6 - 20 ℃; Purification / work up; Resolution of racemate;

upstream raw materials:

methionine methyl ester hydrochloride

DL-methionine

methionine hydrochloride

L-methionine

Downstream raw materials:

(S)-methioninamide hydrochloride

Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

Refernces

• 1、 Zur, Arik A.,Chien, Huan-Chieh,Augustyn, Evan,Flint, Andrew,Heeren, Nathan,Finke, Karissa,Hernandez, Christopher,Hansen, Logan,Miller, Sydney,Lin, Lawrence,Giacomini, Kathleen M.,Colas, Claire,Schlessinger, Avner,Thomas, Allen A.. "LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates". supporting information. p. 5000 - 5006. Retrieved 2016/10/05.
• 2、 Decicco, Carl P.,Grover, Paul. "Asymmetric amino acid synthesis: Mitsunobu reaction on chiral cyanohydrins". . p. 529 - 530. Retrieved 2007/10/03.