3,5-DIFLUOROBENZENESULFONAMIDE

Base Information

• Chemical Name: 3,5-DIFLUOROBENZENESULFONAMIDE
• CAS No.: 140480-89-3
• Molecular Formula: C6H5F2NO2S
• Molecular Weight: 193.174
• Hs Code.: 2935009090
• Mol file: 140480-89-3.mol

Synonyms:3,5-Difluorobenzenesulphonamide;

Chemical Property of 3,5-DIFLUOROBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 2.21E-08mmHg at 25°C
• Melting Point: 157-161 °C(lit.)
• Refractive Index: 1.535
• Boiling Point: 315.855 °C at 760 mmHg
• PKA: 9.66±0.60(Predicted)
• Flash Point: 144.824 °C
• PSA: 68.54000
• Density: 1.523 g/cm³
• LogP: 2.39330

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Difluorobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIFLUOROBENZENESULFONAMIDE

There total 2 articles about 3,5-DIFLUOROBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3,5-difluorobenzenesulfonyl chloride (210532-25-5) → 3,5-difluorobenzenesulfonamide (140480-89-3)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; water; for 1h; Cooling with ice;

Reference yield:

3,5-difluoroaniline (372-39-4) → 3,5-difluorobenzenesulfonamide (140480-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. HCl, NaNO₂, 2.) SO₂, CuCl₂*2H₂O / 1) water, -4 deg C; 2) water, 4 deg C, 35 min

2: aq. NH₃ / 1 h / 0 - 20 °C

With hydrogenchloride; ammonium hydroxide; sulfur dioxide; sodium nitrite;

Reference yield: 96.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 3,5-difluorobenzenesulfonamide (140480-89-3) → N'-(3,5-difluorophenylsulfonyl)-N,N-dimethylformimidamide (1239964-25-0)

Guidance literature:

In acetonitrile; for 1h;

upstream raw materials:

3,5-difluorobenzenesulfonyl chloride

3,5-difluoroaniline

Downstream raw materials:

C₁₆H₁₂F₂N₂O₄S

C₂₅H₂₂Cl₂F₂N₂O₄S

C₂₅H₂₂F₄N₂O₄S

C₂₅H₂₃F₃N₂O₄S

Refernces

• 1、 -. "TGR5 AGONISTS". Page/Page column 169. . Retrieved 2011/06/26.
• 2、 Veenstra,Gerig. "Fluorine NMR studies of the human carbonic anhydrase-3,5-difluorobenzenesulfonamide complex". . p. S169-S178. Retrieved 2007/10/03.