4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER
• CAS No.: 56893-25-5
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.084
• Hs Code.: 2917399590
• Mol file: 56893-25-5.mol

Synonyms:Benzoicacid, 4-(bromoacetyl)-, methyl ester (9CI);4-(2-Bromoacetyl)benzoic acidmethyl ester;Methyl 4-(bromoacetyl)benzoate;Methyl p-(bromoacetyl)benzoate;a-Bromo-4-(carbomethoxy)acetophenone;w-Bromoacetophenone-4-carboxylicacid methyl ester;

Chemical Property of 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 342.783 °C at 760 mmHg
• Flash Point: 161.11 °C
• PSA: 43.37000
• Density: 1.494 g/cm³
• LogP: 2.05080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-(2-Bromoacetyl)benzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER

There total 16 articles about 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(bromoethynyl)benzoic acid methyl ester (225928-10-9) → methyl 4-(2-bromoacetyl)benzoate (56893-25-5)

Guidance literature:

With water; In 1,2-dichloro-ethane; at 20 ℃; for 14h;

DOI:10.1080/00397911.2018.1528616

Reference yield: 91.8%

methyl 4-acetylbenzoate (3609-53-8) → methyl-4-(2′,2′-dibromoacetyl)benzoate (550366-66-0) + methyl 4-(2-bromoacetyl)benzoate (56893-25-5)

Guidance literature:

With bromine; In acetic acid; at 20 ℃; for 1.7h;

Reference yield: 91.0%

methyl 4-acetylbenzoate (3609-53-8) → methyl 4-(2-bromoacetyl)benzoate (56893-25-5)

Guidance literature:

DOI:10.1021/ja9939441

upstream raw materials:

diazomethane

4-Methoxycarbonylbenzoyl chloride

methyl 4-acetylbenzoate

4-acetyl-benzoic acid

Downstream raw materials:

4-[2-(2-Oxo-2H-pyridin-1-yl)-acetyl]-benzoic acid methyl ester

2-amino-4-(4′-methoxycarbonylphenyl)thiazole

4-(4,5,7,8,9,10-Hexahydro-7,7,10,10-tetramethylanthra-[1,2-b]furan-2-yl)benzoic acid

Methyl 4-{3-[3-(t-butoxycarbonyl)amino]propyl-2-(phenylimino)-2,3-dihydrothiazol-4-yl}benzoate

Refernces

• 1、 -. "Heterocyclic compound as well as preparation method and application thereof". Paragraph 0120-0123; 0126; 0127. . Retrieved 2021/02/06.
• 2、 Fu, Haigen,Lam, Heather,Emmanuel, Megan A.,Kim, Ji Hye,Sandoval, Braddock A.,Hyster, Todd K.. "Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions". supporting information. p. 9622 - 9629. Retrieved 2021/07/01.