2-Morpholinoacetaldehyde

Base Information

• Chemical Name: 2-Morpholinoacetaldehyde
• CAS No.: 21977-09-3
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• DSSTox Substance ID: DTXSID10364004
• Wikidata: Q82147781
• Mol file: 21977-09-3.mol

Synonyms:2-Morpholinoacetaldehyde;21977-09-3;2-morpholin-4-ylacetaldehyde;morpholin-4-yl-acetaldehyde;4-Morpholineacetaldehyde;Morpholin-4-yl acetaldehyde;Morpholin-4-ylacetaldehyde;2-oxoethylmorpholine;SCHEMBL165786;2-(morpholin-4-yl)acetaldehyde;DTXSID10364004;WAA97709;MFCD05663331;AKOS010079620;BB 0251251;FT-0678412;EN300-316772;F17543;A848124

Chemical Property of 2-Morpholinoacetaldehyde

Chemical Property:

• Boiling Point: 308.4 °C at 760 mmHg
• PKA: 5.31±0.10(Predicted)
• Flash Point: 140.3 °C
• PSA: 29.54000
• Density: 1.046 g/cm³
• LogP: -0.54460
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.078978594
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

NLT 98% ^*data from raw suppliers

Morpholin-4-ylacetaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC=O

Technology Process of 2-Morpholinoacetaldehyde

There total 3 articles about 2-Morpholinoacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2,2-diethoxy-ethyl)-morpholine (3616-59-9) → morpholin-4-ylacetaldehyde (21977-09-3)

Guidance literature:

With hydrogenchloride; In methanol; water; Reflux; Inert atmosphere;

DOI:10.1039/c1ob05830d

Reference yield:

4-(2,2-dimethoxyethyl)morpholine (22633-57-4) → morpholin-4-ylacetaldehyde (21977-09-3)

Guidance literature:

With hydrogenchloride; at 70 ℃;

DOI:10.1016/j.bmc.2007.06.054

Reference yield:

→ morpholin-4-ylacetaldehyde (21977-09-3)

Guidance literature:

1,2-Dimorpholino-ethylen, HCl;

upstream raw materials:

4-(2,2-dimethoxyethyl)morpholine

4-(2,2-diethoxy-ethyl)-morpholine

Refernces

• 1、 -. "MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN". Paragraph 0299-0300. . Retrieved 2017/12/07.
• 2、 Wang, Yuanxiang,Ai, Jing,Liu, Gang,Geng, Meiyu,Zhang, Ao. "Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors". supporting information; scheme or table. p. 5930 - 5933. Retrieved 2011/10/08.