N-(4-Bromo-2,6-dichlorophenyl)acetamide

Base Information

• Chemical Name: N-(4-Bromo-2,6-dichlorophenyl)acetamide
• CAS No.: 13953-09-8
• Molecular Formula: C8H6 Br Cl2 N O
• Molecular Weight: 282.952
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40504658
• Nikkaji Number: J1.072.016H
• Wikidata: Q82359308
• Mol file: 13953-09-8.mol

Synonyms:N-(4-BROMO-2,6-DICHLOROPHENYL)ACETAMIDE;13953-09-8;Acetamide, N-(4-bromo-2,6-dichlorophenyl)-;Acetamide,N-(4-bromo-2,6-dichlorophenyl)-;DTXSID40504658;MFCD08703152;AKOS008969096;DS-16273;CS-0153988;C72576;N-(4-Bromo-2 pound not6-dichlorophenyl)acetamide

Chemical Property of N-(4-Bromo-2,6-dichlorophenyl)acetamide

Chemical Property:

• Melting Point: 208-209 °C
• Boiling Point: 408.6 °C at 760 mmHg
• PKA: 12.39±0.70(Predicted)
• Flash Point: 200.9 °C
• PSA: 29.10000
• Density: 1.74 g/cm³
• LogP: 3.78730
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 280.90098
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Bromo-2,6-dichlorophenyl)acetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1Cl)Br)Cl

Technology Process of N-(4-Bromo-2,6-dichlorophenyl)acetamide

There total 7 articles about N-(4-Bromo-2,6-dichlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,6-dichloroacetanilide (17700-54-8) → 4-bromo-2,6-dichloroacetanilide (13953-09-8)

Guidance literature:

With hydrogen bromide; bromine; In acetic acid; for 0.5h; Heating;

Reference yield:

4-bromo-2,6-dichloroaniline (697-88-1) + acetic anhydride (108-24-7) → 4-bromo-2,6-dichloroacetanilide (13953-09-8)

Guidance literature:

With sulfuric acid; In acetic acid; at 20 ℃; for 1h;

Reference yield:

2,6-Dichloroaniline (608-31-1) → 4-bromo-2,6-dichloroacetanilide (13953-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂; AcOH / 0.5 h / 20 °C

2: H₂SO₄ / acetic acid / 1 h / 20 °C

With sulfuric acid; bromine; acetic acid; In acetic acid;

upstream raw materials:

4-bromo-2,6-dichloroaniline

acetyl chloride

4-bromoacetanilide

2,6-dichloroacetanilide

Downstream raw materials:

N-<2,6-Dichloro-3-(dimethylsulfamoyl)phenyl>anthranilic acid

3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide

3-Acetamido-2,4-dichlorobenzenesulfonyl chloride

3-Amino-2,4-dichloro-N¹,N¹-dimethylbenzenesulfonamide

Refernces

• 1、 Ferguson, George,Low, John N.,Penner, Glenn H.,Wardell, James L.. "2,4,6-Halogeno-aniline derivatives". . p. 1974 - 1977. Retrieved 2007/10/03.