3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide

Base Information

• Chemical Name: 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide
• CAS No.: 73323-89-4
• Molecular Formula: C₁₀H₁₂Cl₂N₂O₃S
• Molecular Weight: 311.189
• Mol file: 73323-89-4.mol

Synonyms:

Chemical Property of 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide

There total 5 articles about 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2,6-dichloroacetanilide (13953-09-8) → 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide (73323-89-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 53.5 g / conc. nitric acid / H₂SO₄ / 1 h / Ambient temperature

2: H₂ / Raney nickel / methanol

3: 30.1 g / H₂, sodium acetate / 20percent Pd/C / ethanol

4: 1.) HCl, sodium nitrite, 2.) sulfur dioxide, acetic acid, cupric chloride dihydrate / 1.) Water, 2-4 deg C, 30 min, 2.) water, cooling, 1 h

With hydrogenchloride; sulfur dioxide; hydrogen; nitric acid; sodium acetate; acetic acid; copper dichloride; sodium nitrite; palladium on activated charcoal; nickel; In methanol; ethanol; sulfuric acid;

DOI:10.1021/jo01299a020

Reference yield:

4'-Bromo-2',6'-dichloro-3'-nitroacetanilide (13953-10-1) → 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide (73323-89-4)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Raney nickel / methanol

2: 30.1 g / H₂, sodium acetate / 20percent Pd/C / ethanol

3: 1.) HCl, sodium nitrite, 2.) sulfur dioxide, acetic acid, cupric chloride dihydrate / 1.) Water, 2-4 deg C, 30 min, 2.) water, cooling, 1 h

With hydrogenchloride; sulfur dioxide; hydrogen; sodium acetate; acetic acid; copper dichloride; sodium nitrite; palladium on activated charcoal; nickel; In methanol; ethanol;

DOI:10.1021/jo01299a020

Reference yield:

4'-Bromo-2',6'-dichloro-3'-aminoacetanilide (73323-87-2) → 3-Acetamido-2,4-dichloro-N,N-dimethylbenzenesulfonamide (73323-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 30.1 g / H₂, sodium acetate / 20percent Pd/C / ethanol

2: 1.) HCl, sodium nitrite, 2.) sulfur dioxide, acetic acid, cupric chloride dihydrate / 1.) Water, 2-4 deg C, 30 min, 2.) water, cooling, 1 h

With hydrogenchloride; sulfur dioxide; hydrogen; sodium acetate; acetic acid; copper dichloride; sodium nitrite; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01299a020

upstream raw materials:

3-Acetamido-2,4-dichlorobenzenesulfonyl chloride

dimethyl amine

N-(3-amino-2,6-dichlorophenyl)acetamide

4-bromo-2,6-dichloroacetanilide

Downstream raw materials:

N-<2,6-Dichloro-3-(dimethylsulfamoyl)phenyl>anthranilic acid

3-Amino-2,4-dichloro-N¹,N¹-dimethylbenzenesulfonamide

Refernces