Technology Process of (17R,18S,19S,20S,21S,22S)-18,19,20,21,22-Pentakis-benzyloxy-25-((S)-1-tert-butoxycarbonyl-2-methyl-propylcarbamoyl)-17-hydroxy-pentacos-14-ynoic acid
There total 19 articles about (17R,18S,19S,20S,21S,22S)-18,19,20,21,22-Pentakis-benzyloxy-25-((S)-1-tert-butoxycarbonyl-2-methyl-propylcarbamoyl)-17-hydroxy-pentacos-14-ynoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 7.7 g / Et3N / CH2Cl2 / 20 °C
2: 68 percent / n-BuLi; BF3*Et2O / tetrahydrofuran; diethyl ether / 5.5 h / -95 - -78 °C
3: TBAF / tetrahydrofuran / 0.17 h / 0 °C
With
n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol061582d
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
DOI:10.1021/ol061582d
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / Pd/C / methanol
2: SO3*pyridine; DMSO; (i-Pr)2NEt / CH2Cl2 / 0.5 h / 20 °C
3: 2.05 g / K2CO3 / 2 h / 20 °C
4: LiOH; H2O / tetrahydrofuran / 13 h / 0 - 20 °C
5: 7.7 g / Et3N / CH2Cl2 / 20 °C
6: 68 percent / n-BuLi; BF3*Et2O / tetrahydrofuran; diethyl ether / 5.5 h / -95 - -78 °C
7: TBAF / tetrahydrofuran / 0.17 h / 0 °C
With
lithium hydroxide; n-butyllithium; pyridine-SO3 complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; hydrogen; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol061582d
