(4-Bromophenyl)(4-chlorophenyl)methanone

Base Information

• Chemical Name: (4-Bromophenyl)(4-chlorophenyl)methanone
• CAS No.: 27428-57-5
• Molecular Formula: C13H8BrClO
• Molecular Weight: 295.563
• Hs Code.: 2914700090
• European Community (EC) Number: 675-384-1
• DSSTox Substance ID: DTXSID60373601
• Nikkaji Number: J307.806J
• Wikidata: Q82161826
• Mol file: 27428-57-5.mol

Synonyms:27428-57-5;(4-bromophenyl)(4-chlorophenyl)methanone;4-Bromo-4'-chlorobenzophenone;(4-bromophenyl)-(4-chlorophenyl)methanone;Methanone,(4-bromophenyl)(4-chlorophenyl)-;4'-Bromo-4-chlorobenzophenone;SCHEMBL3156716;DTXSID60373601;FYMCXGILCMIOKD-UHFFFAOYSA-N;CBA42857;MFCD00045208;AKOS009339253;FS-5070;AM803619;B4224;CS-0037173;FT-0752463;Methanone, (4-bromophenyl)(4-chlorophenyl)-;A18555;J-016763

Chemical Property of (4-Bromophenyl)(4-chlorophenyl)methanone

Chemical Property:

• Vapor Pressure: 4.64E-06mmHg at 25°C
• Melting Point: 148.0 to 152.0 °C
• Refractive Index: 1.618
• Boiling Point: 382.7 °C at 760 mmHg
• Flash Point: 185.2 °C
• PSA: 17.07000
• Density: 1.51 g/cm³
• LogP: 4.33350
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 293.94471
• Heavy Atom Count: 16
• Complexity: 240

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-4'-chlorobenzophenone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)Br)Cl

Technology Process of (4-Bromophenyl)(4-chlorophenyl)methanone

There total 18 articles about (4-Bromophenyl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1.4-dibromobenzene (106-37-6) + 4-chlorobenzaldehyde (104-88-1) → 4-bromo-4'-chlorobenzophenone (27428-57-5)

Guidance literature:

1.4-dibromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-chlorobenzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h;

With iodine; potassium carbonate; In tert-butyl alcohol; for 3h; Reflux;

DOI:10.1016/j.tet.2011.12.023

Reference yield: 85.0%

carbon monoxide (201230-82-2) + 1,4-bromoiodobenzene (589-87-7) + 4-Chlorophenylboronic acid (1679-18-1) → 4-bromo-4'-chlorobenzophenone (27428-57-5)

Guidance literature:

With potassium carbonate; In methoxybenzene; at 80 ℃; for 7h; under 760.051 Torr;

DOI:10.1039/c0gc00138d

Reference yield: 85.0%

carbon monoxide (201230-82-2) + 1,4-bromoiodobenzene (589-87-7) + tributyl(4-chlorophenyl)stannane (17151-48-3) → 4-bromo-4'-chlorobenzophenone (27428-57-5)

Guidance literature:

With MCM-41-supported bidentate phosphine palladium⁽⁰⁾ complex; In N,N-dimethyl-formamide; at 80 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/b914844m

upstream raw materials:

bromobenzene

4-chloro-benzoyl chloride

chlorobenzene

4-chlorobenzoyl chloride

Downstream raw materials:

1-((4-bromophenyl)-(4-chlorophenyl))methanol

(4-bromo-phenyl)-dichloro-(4-chloro-phenyl)-methane

dioxolanne de la chloro-4 bromo-4' benzophenone

2-(4-bromophenyl)-4-chloromethyl-2-(4-chlorophenyl)-1,3-dioxolane

Refernces

• 1、 Hu, Yingying,Shao, Yu,Zhang, Shuwei,Yuan, Yuan,Sun, Zheng,Yuan, Yu,Jia, Xiaodong. "AIBN initiated functionalization of the benzylic sp3 C[sbnd]H and C[sbnd]C bonds in the presence of dioxygen". supporting information. . Retrieved 2021/02/01.
• 2、 Bian, Mengying,Zhao, Zifeng,Li, Yu,Li, Qing,Chen, Zhijian,Zhang, Dongdong,Wang, Shufeng,Bian, Zuqiang,Liu, Zhiwei,Duan, Lian,Xiao, Lixin. "A combinational molecular design to achieve highly efficient deep-blue electrofluorescence". . p. 745 - 753. Retrieved 2018/02/07.