(2R)-2-AMINO-2-PHENYLBUTANOIC ACID

Base Information

• Chemical Name: (2R)-2-AMINO-2-PHENYLBUTANOIC ACID
• CAS No.: 33875-38-6
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922499990
• Mol file: 33875-38-6.mol

Synonyms:Benzeneaceticacid, a-amino-a-ethyl-, (R)- (9CI);Butyricacid, 2-amino-2-phenyl-, (R)-(-)- (8CI);(2R)-2-Amino-2-phenylbutanoic acid;(-)-(R)-2-Amino-2-phenylbutyric acid;

Chemical Property of (2R)-2-AMINO-2-PHENYLBUTANOIC ACID

Chemical Property:

• Vapor Pressure: 0.000231mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 312.1 °C at 760 mmHg
• Flash Point: 142.5 °C
• PSA: 63.32000
• Density: 1.16 g/cm³
• LogP: 2.03550

Purity/Quality:

98%min ^*data from raw suppliers

(2R)-2-Amino-2-phenylbutanoicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-2-AMINO-2-PHENYLBUTANOIC ACID

There total 14 articles about (2R)-2-AMINO-2-PHENYLBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (R)-2-(methoxycarbonylamino)-2-phenylbutanoate (1073529-51-7) → (R)-2‐amino‐2‐phenylbutyric acid (33875-38-6)

Guidance literature:

methyl (R)-2-(methoxycarbonylamino)-2-phenylbutanoate; With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃; for 48h;

With ammonium hydroxide; In water;

DOI:10.1002/anie.200802439

Reference yield: 99.0%

(-)-Mephenytoin (71140-51-7) → (R)-2‐amino‐2‐phenylbutyric acid (33875-38-6)

Guidance literature:

With sodium hydroxide; for 96h; Reflux;

DOI:10.1002/anie.201502569

Reference yield:

(-)-Nirvanol (65567-32-0) → (R)-2‐amino‐2‐phenylbutyric acid (33875-38-6)

Guidance literature:

With water; sodium hydroxide; at 130 ℃; for 48h; Autoclave;

upstream raw materials:

(2S,4S)-3-benzyloxycarbonyl-2,4-diphenyl-1,3-oxazolidin-5-one

methyl (R)-2-(methoxycarbonylamino)-2-phenylbutanoate

(-)-Nirvanol

2-amino-2-phenylbutanoic acid

Downstream raw materials:

(-)-Nirvanol

(R)-2-ureido-2-phenyl-butyric acid

Refernces

• 1、 Netz, Isabelle,Kucukdisli, Murat,Opatz, Till. "Enantioselective Synthesis of α-Quaternary Amino Acids by Alkylation of Deprotonated α-Aminonitriles". . p. 6864 - 6869. Retrieved 2015/10/06.
• 2、 -. "COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS". Page/Page column 45-49; 61. . Retrieved 2010/12/31.