3-Chlorophenylmagnesium bromide

Base Information

• Chemical Name: 3-Chlorophenylmagnesium bromide
• CAS No.: 36229-42-2
• Molecular Formula: C6H4BrClMg
• Molecular Weight: 215.76
• Hs Code.: 29319090
• European Community (EC) Number: 680-755-6
• Mol file: 36229-42-2.mol

Synonyms:36229-42-2;3-Chlorophenylmagnesium bromide;(3-chlorophenyl)magnesium bromide;MFCD00672003;3-Chlorophenylmagnesium bromide, 1.0 M in THF;magnesium;chlorobenzene;bromide;3-chlorophenyl magnesium bromide;3-CHLOROPHENYLMAGNESIUMBROMIDE;m-chlorophenylmagnesium bromide;SCHEMBL538608;m-chlorophenyl magnesium bromide;3-Chlorophenylmagnesium bromide 0.5 M in Tetrahydrofuran;3-chloro phenyl magnesium bromide;3-chloro-phenyl magnesium bromide;ZIYRUWPTUPFRQU-UHFFFAOYSA-M;(3-chlorophenyl) magnesium bromide;AKOS016018098;3-Chlorophenylmagnesium bromide, 1M in MeTHF;3-Chlorophenylmagnesium bromide, 0.5M in THF;3-Chlorophenylmagnesium bromide, 0.5 M in THF;A857389;3-Chlorophenylmagnesium bromide, 1.0 M in 2-MeTHF

Chemical Property of 3-Chlorophenylmagnesium bromide

Chemical Property:

• Boiling Point: 65 °C(lit.)
• Flash Point: 1 °F
• PSA: 0.00000
• Density: 0.960 g/mL at 25 °C(lit.)
• LogP: 2.98580
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 213.90353
• Heavy Atom Count: 9
• Complexity: 149

Purity/Quality:

99.0% ^*data from raw suppliers

3-Chlorophenylmagnesium bromide 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C,F+
• Hazard Codes: F,C,F+,Xn
• Statements: 11-14-19-22-34-40-12-36/37
• Safety Statements: 16-23-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C[C-]=CC(=C1)Cl.[Mg+2].[Br-]
• Uses: 3-Chlorophenylmagnesium bromide is involved in the synthesis of enantiopure 2-imidazolidinones by reacting with 1,1'-DiBoc-2,2'-Biaziridine.

Technology Process of 3-Chlorophenylmagnesium bromide

There total 1 articles about 3-Chlorophenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3-chlorobenzene (108-37-2) → (3-chlorophenyl)magnesium bromide (36229-42-2)

Guidance literature:

With iodine; In diethyl ether;

Reference yield: 93.0%

N,N,N-trimethylbenzeneaminium trifluoromethanesulfonate + (3-chlorophenyl)magnesium bromide (36229-42-2) → m-chlorobiphenyl (2051-61-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol1018739

Reference yield: 89.0%

Methyl 3-formylbenzoate (52178-50-4) + (3-chlorophenyl)magnesium bromide (36229-42-2) → methyl 3-[(3-chlorophenyl)(hydroxy)methyl]benzoate (1093865-16-7)

Guidance literature:

Methyl 3-formylbenzoate; (3-chlorophenyl)magnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water;

upstream raw materials:

1-bromo-3-chlorobenzene

Downstream raw materials:

2-(3-chloro-benzoyl)-[1]naphthoic acid

(3-chloro-phenyl)-(1-methyl-[4]piperidyl)-phenyl-methanol

1-(m-Chlorophenyl)ethanol

2,2,2-trichloro-1-(3-chlorophenyl)ethan-1-ol

Refernces

• 1、 -. "Platinum complex and light-emitting device". Page/Page column 30-31. . Retrieved 2010/11/23.