12-HYDROXYSTEARIC ACID ETHYL ESTER

Base Information

• Chemical Name: 12-HYDROXYSTEARIC ACID ETHYL ESTER
• CAS No.: 74815-67-1
• Molecular Formula: C20H40O3
• Molecular Weight: 328.536
• Mol file: 74815-67-1.mol

Synonyms:Ethyl12-hydroxystearate;Ethyl DL-12-hydroxyoctadecanoate;

Chemical Property of 12-HYDROXYSTEARIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 51-51.3 °C
• Boiling Point: 414.3 °C at 760 mmHg
• PKA: 15.40±0.20(Predicted)
• Flash Point: 152.3 °C
• PSA: 46.53000
• Density: 0.912 g/cm³
• LogP: 5.78180
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 12-HYDROXYSTEARATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 12-HYDROXYSTEARIC ACID ETHYL ESTER

There total 5 articles about 12-HYDROXYSTEARIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethanol (64-17-5) + 12-Hydroxystearic acid (106-14-9,78642-86-1,8039-23-4,27924-99-8,860114-96-1) → ethyl 12-hydroxystearate (74815-67-1,82807-36-1)

Guidance literature:

With sulfuric acid; at 78 ℃; for 20h; Heating / reflux;

Reference yield: 91.0%

ethyl 12-oxo-octadecanoate (88472-61-1) → ethyl 12-hydroxystearate (74815-67-1,82807-36-1)

Guidance literature:

With hydrogen; nickel; In ethanol; at 150 ℃; for 15h;

Reference yield:

1,12-dodecadicarboxylic acid monoethyl ester (66003-63-2) → ethyl 12-hydroxystearate (74815-67-1,82807-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / SOCl₂ / 4 h / Heating

2: 1) Mg / 1) THF, -78 gradC, 1.5 h; 2) raised to 20 gradC

3: 91 percent / H₂ / Raney nickel / ethanol / 15 h / 150 °C

With thionyl chloride; hydrogen; magnesium; nickel; In ethanol;

upstream raw materials:

ethanol

12-Hydroxystearic acid

ethyl 12-oxo-octadecanoate

1,12-dodecadicarboxylic acid monoethyl ester

Downstream raw materials:

12-Hydroxystearic acid

12-octadecenoic acid

trans-12-Octadecensaeure

petroselinic acid

Refernces

• 1、 Zakharkin, L. I.,Guseva, V. V.,Churilova, I. M.. "SYNTHESIS OF 12-HYDROXYCARBOXYLIC ACIDS FROM 11-CYANOUNDECANOIC ACID". . p. 1632 - 1634. Retrieved 2007/10/02.