2-CHLORO-4-HYDROXYQUINAZOLINE

Base Information

• Chemical Name: 2-CHLORO-4-HYDROXYQUINAZOLINE
• CAS No.: 607-69-2
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.593
• Hs Code.: 2933990090
• Mol file: 607-69-2.mol

Synonyms:4(1H)-Quinazolinone,2-chloro- (9CI);2-Chloro-3,4-dihydro-4-oxoquinazoline;2-Chloro-4(1H)-quinazolinone;2-Chloro-4(3H)-quinazolinone;2-Chloro-4-hydroxyquinazoline;2-Chloro-4-quinazolinol;2-Chloroquinazolin-4-one;

Chemical Property of 2-CHLORO-4-HYDROXYQUINAZOLINE

Chemical Property:

• Vapor Pressure: 0.000223mmHg at 25°C
• Melting Point: 218-220℃
• Refractive Index: 1.688
• Boiling Point: 325.9 °C at 760 mmHg
• PKA: -2.12±0.20(Predicted)
• Flash Point: 150.9 °C
• PSA: 46.01000
• Density: 1.5 g/cm³
• LogP: 1.98880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloroquinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4-HYDROXYQUINAZOLINE

There total 2 articles about 2-CHLORO-4-HYDROXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

chlorodibromomethane (124-48-1) + anthranilic acid amide (28144-70-9,88-68-6) → 2-chloro-4-hydroxy-quinazoline (607-69-2)

Guidance literature:

With dibenzo-18-crown-6; potassium acetate; copper; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

Reference yield:

1-Methylpyrrolidine (120-94-5) + 1,2,3,4-tetrahydro-quinazoline-2,4-dione (86-96-4) → 2-chloro-4(3H)-quinazolinone (607-69-2) + 2,4-dichloroquinazoline (607-68-1) + 4-chloro-2-quinazoline (81093-71-2) + 2--4(3H)-quinazoline (84148-67-4)

Guidance literature:

With trichlorophosphate; Product distribution; Mechanism; ratio of products vs. conditions;

DOI:10.1248/cpb.30.3121

Reference yield: 90.0%

2-chloro-4(3H)-quinazolinone (607-69-2) → 2,4-dichloroquinazoline (607-68-1)

Guidance literature:

With 1-Methylpyrrolidine; trichlorophosphate; at 20 - 25 ℃; for 0.5h;

DOI:10.1248/cpb.30.3121

upstream raw materials:

1-Methylpyrrolidine

1,2,3,4-tetrahydro-quinazoline-2,4-dione

chlorodibromomethane

anthranilic acid amide

Downstream raw materials:

2-[(4-chlorophenyl)amino]quinazolin-4(3H)-one

2-((4-methoxyphenyl)amino)quinazolin-4(3H)-one

2-anilinoquinazolin-4(3H)-one

2-(4-chloro-phenylsulfanyl)-3H-quinazolin-4-one

Refernces

• 1、 Miki. "Fused pyrimidines. II. Formation mechanism of 2-[N-alkyl-N-(ω-chloroalkyl)amino]-4-chloroquinazolines". . p. 3121 - 3124. Retrieved 2007/10/02.