(4-Methoxypyridin-2-yl)methanol

Base Information

• Chemical Name: (4-Methoxypyridin-2-yl)methanol
• CAS No.: 16665-38-6
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• European Community (EC) Number: 803-208-7
• DSSTox Substance ID: DTXSID20445272
• Mol file: 16665-38-6.mol

Synonyms:(4-methoxypyridin-2-yl)methanol;16665-38-6;(4-Methoxy-pyridin-2-yl)-methanol;4-METHOXY-2-PYRIDINEMETHANOL;2-PYRIDINEMETHANOL, 4-METHOXY-;4-METHOXY-2-HYDROXYMETHYLPYRIDINE;4-METHOXYPYRIDINE-2-METHANOL;MFCD07774100;2-Pyridinemethanol,4-methoxy-;2-(Hydroxymethyl)-4-methoxypyridine;4-methoxypyrid-2-ylmethanol;SCHEMBL245100;(4-methoxy-2-pyridinyl)methanol;DTXSID20445272;GBMRUSRMPOUVEK-UHFFFAOYSA-N;AMY10096;AKOS005064337;AB42298;DS-3011;2-HYDROXYMETHYL-4-METHOXYPYRIDINE;SY106603;CS-0030488;FT-0649469;EN300-64545;(4-Methoxy-pyridin-2-yl)-methanol, AldrichCPR;A810752;J-501429;Z800297980

Chemical Property of (4-Methoxypyridin-2-yl)methanol

Chemical Property:

• Melting Point: 69-70 °C
• Boiling Point: 261.639 °C at 760 mmHg
• PKA: 13.22±0.10(Predicted)
• Flash Point: 112.036 °C
• PSA: 42.35000
• Density: 1.155 g/cm³
• LogP: 0.58250
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%min ^*data from raw suppliers

(4-Methoxypyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC=C1)CO

Technology Process of (4-Methoxypyridin-2-yl)methanol

There total 24 articles about (4-Methoxypyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-methoxypyridin-2-yl)methyl acetate (16665-37-5) → 4-methoxy-2-(hydroxymethyl)pyridine (16665-38-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; Alkaline conditions;

DOI:10.1021/acs.jmedchem.8b00964

Reference yield: 96.0%

(4-chloropyridin-2-yl)methanol (63071-10-3) + sodium methylate (124-41-4) → 4-methoxy-2-(hydroxymethyl)pyridine (16665-38-6)

Guidance literature:

In methanol; for 16h; Reflux;

DOI:10.1021/acs.jmedchem.0c01573

Reference yield: 95.0%

4-methoxypyridine-2-carbaldehyde (16744-81-3) → 4-methoxy-2-(hydroxymethyl)pyridine (16665-38-6)

Guidance literature:

With formic acid; C₂₀H₂₉ClIrN₄⁽¹⁺⁾*Cl^(1-); In water; at 80 ℃; for 0.25h; chemoselective reaction;

DOI:10.1039/c7gc01289f

upstream raw materials:

4-methoxy-2-methylpyridine 1-oxide

diazomethane

4-Acetoxy-2-acetoxymethylpyridine

methanol

Downstream raw materials:

4-methoxypyridine-2-carbaldehyde

4-Methoxy-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-[2-(benzyl-methyl-amino)-ethyl] ester 3'-methyl ester

6-(4-Methoxy-phenyl)-2-(4-methoxy-pyridin-2-ylmethanesulfinyl)-3H-thieno[3,4-d]imidazole

6-(4-Methoxy-phenyl)-2-(4-methoxy-pyridin-2-ylmethylsulfanyl)-3H-thieno[3,4-d]imidazole

Refernces

• 1、 -. "DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX". . . Retrieved 2021/03/19.
• 2、 Wang, Junfeng,Wang, Huan,Ramsay, Ian A.,Erstad, Derek J.,Fuchs, Bryan C.,Tanabe, Kenneth K.,Caravan, Peter,Gale, Eric M.. "Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation". . p. 8811 - 8824. Retrieved 2018/10/09.