4-Methoxypicolinaldehyde

Base Information

• Chemical Name: 4-Methoxypicolinaldehyde
• CAS No.: 16744-81-3
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 2933399090
• European Community (EC) Number: 695-353-6
• DSSTox Substance ID: DTXSID90489466
• Nikkaji Number: J2.951.041E
• Wikidata: Q82332790
• Mol file: 16744-81-3.mol

Synonyms:4-methoxypicolinaldehyde;16744-81-3;4-methoxypyridine-2-carbaldehyde;4-Methoxypyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde, 4-methoxy-;MFCD08234865;4-METHOXY-2-FORMYLPYRIDINE;SCHEMBL1208300;4-methoxypyridin-2-carbaldehyde;AMY8044;DTXSID90489466;UEVABMBUZNGYQI-UHFFFAOYSA-N;AKOS006287191;AB43663;CS-W004971;4-METHOXY-2-PYRIDINECARBOXALDEHYDE;AC-33269;DS-15379;SY067656;FT-0699752;EN300-316823;Z1198176555

Chemical Property of 4-Methoxypicolinaldehyde

Chemical Property:

• Vapor Pressure: 0.042mmHg at 25°C
• Melting Point: 28-30℃
• Refractive Index: 1.551
• Boiling Point: 238.651 °C at 760 mmHg
• PKA: 4.47±0.10(Predicted)
• Flash Point: 98.133 °C
• PSA: 39.19000
• Density: 1.159 g/cm³
• LogP: 0.90270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 137.047678466
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

≥99.0% ^*data from raw suppliers

4-Methoxypicolinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC=C1)C=O

Technology Process of 4-Methoxypicolinaldehyde

There total 14 articles about 4-Methoxypicolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methoxy-2-(hydroxymethyl)pyridine (16665-38-6) → 4-methoxypyridine-2-carbaldehyde (16744-81-3)

Guidance literature:

With manganese(IV) oxide; In chloroform; at 80 ℃; for 24h;

Reference yield: 85.0%

methyl 4-methoxypicolinate (29681-43-4) → 4-methoxypyridine-2-carbaldehyde (16744-81-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol200478p

Reference yield: 57.0%

ethyl 4-methoxypicolinate → 4-methoxypyridine-2-carbaldehyde (16744-81-3)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3h; Inert atmosphere;

upstream raw materials:

4-methoxy-2-(hydroxymethyl)pyridine

2-methylpyridine N-oxide

2-methyl-4-nitropyridine N-oxide

4-Acetoxy-2-acetoxymethylpyridine

Downstream raw materials:

C₁₄H₁₅N₃O₃S

4-methoxy-2-(hydroxymethyl)pyridine

4-Methoxy-2',6'-dimethyl-1',4'-dihydro-[2,4']bipyridinyl-3',5'-dicarboxylic acid 5'-[2-(benzyl-methyl-amino)-ethyl] ester 3'-methyl ester

1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

Refernces

• 1、 -. "DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX". Paragraph 0076; 0078-0079. . Retrieved 2021/03/19.
• 2、 Fuchida, Hirokazu,Tabata, Shigekazu,Shindo, Naoya,Takashima, Ippei,Leng, Qiao,Hatsuyama, Yuji,Hamachi, Itaru,Ojida, Akio. "Design of coordination interaction of Zn(II) complex with oligo-aspartate peptide to afford a high-affinity tag-probe pair". supporting information. p. 784 - 791. Retrieved 2015/06/25.