2-Amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid
• CAS No.: 53284-84-7
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Hs Code.: 2932990090
• European Community (EC) Number: 674-838-6
• DSSTox Substance ID: DTXSID90392002
• Nikkaji Number: J2.687.903E
• Mol file: 53284-84-7.mol

Synonyms:53284-84-7;2-amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid;4'-Tetrahydropyranylglycine;2-amino-2-(oxan-4-yl)acetic Acid;4-TETRAHYDROPYRANYLGLYCINE;2-(Tetrahydropyran-4-yl)glycine;amino-(tetrahydro-pyran-4-yl)-acetic acid;2H-Pyran-4-acetic acid,a-aminotetrahydro-;(R)-a-Aminotetrahydro-2H-pyran-4-acetic acid;MFCD03419267;2-amino-2-tetrahydropyran-4-yl-acetic acid;MFCD01631205;(+/-)-4'-Tetrahydropyranylglycine;2-(Tetrahydro-pyran-4-yl)-glycine;(R)-2-Amino-2-(4-tetrahydropyranyl)acetic Acid;SCHEMBL1770232;( inverted exclamation markA)-4'-Tetrahydropyranylglycine;DTXSID90392002;XLZJPHKIECMDPG-UHFFFAOYSA-N;BCP16988;CS-D0012;D-4-TETRAHYDROPYRANYLGLYCINE;L-4-TETRAHYDROPYRANYLGLYCINE;AMINO(OXAN-4-YL)ACETIC ACID;MFCD02183576;AKOS011672383;amino-(4-tetrahydropyranyl)acetic acid;AB88771;AB89441;AC-6477;PB10222;SB21656;BS-28650;HY-20838;PD195937;SY030310;SY060235;A7752;AM20100305;FT-0650250;FT-0654038;FT-0687258;EN300-69837;(S)-a-Aminotetrahydro-2H-pyran-4-acetic acid;2-amino-2-(tetrahydro-2h-pyran-4-yl)aceticacid;(S)-2-Amino-2-(tetrahydropyran-4-yl)acetic Acid;Q-103224;amino-(tetrahydro-pyran-4-yl)-acetic acid, AldrichCPR;F8887-4130

Chemical Property of 2-Amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid

Chemical Property:

• Boiling Point: 316.7 °C at 760 mmHg
• PKA: 2.25±0.10(Predicted)
• Flash Point: 145.3 °C
• PSA: 72.55000
• Density: 1.211g/cm³
• LogP: 0.52520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 159.08954328
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-2-(tetrahydro-2H-pyran-4-yl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCC1C(C(=O)O)N

Technology Process of 2-Amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid

There total 1 articles about 2-Amino-2-(tetrahydro-2h-pyran-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde (50675-18-8) + potassium cyanide (151-50-8) → 2-amino-2-(oxan-4-yl)acetic acid (53284-84-7,475649-32-2)

Guidance literature:

With methanol; ammonium chloride;

Reference yield:

2-amino-2-(oxan-4-yl)acetic acid (53284-84-7,475649-32-2) → 3-bromo-4-((2-hydroxy-1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)-5-nitrobenzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 60 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 80 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;

Reference yield:

2-amino-2-(oxan-4-yl)acetic acid (53284-84-7,475649-32-2) → 2-amino-2-(tetrahydro-2H-pyran-4-yl)ethanol (889949-63-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 ℃; for 3h;

upstream raw materials:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

potassium cyanide

Downstream raw materials:

2-amino-2-(tetrahydro-2H-pyran-4-yl)ethanol