3'-O-METHYLURIDINE

Base Information

• Chemical Name: 3'-O-METHYLURIDINE
• CAS No.: 6038-59-1
• Molecular Formula: C₁₀H₁₄N₂O₆
• Molecular Weight: 258.231
• Hs Code.: 29349990
• Mol file: 6038-59-1.mol

Synonyms:3'-O-Methyluridine

Chemical Property of 3'-O-METHYLURIDINE

Chemical Property:

• PSA: 113.78000
• Density: 1.53g/cm3
• LogP: -2.19780
• Storage Temp.: −20°C

Purity/Quality:

98%Min ^*data from raw suppliers

3'-O-Methyluridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-O-METHYLURIDINE

There total 4 articles about 3'-O-METHYLURIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C25H28N2O7 (1213263-37-6) → 3'-O-methyluridine (6038-59-1,55062-69-6)

Guidance literature:

With formic acid; palladium on activated charcoal; hydrogen; In water; isopropyl alcohol; for 12h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2012.05.035

Reference yield: 83.0%

3'-O-methyl-5'-O-(monomethoxytrityl)uridine (174020-29-2) → 3'-O-methyluridine (6038-59-1,55062-69-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1002/hlca.19960790808

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + uridine (58-96-8) → 3'-O-methyluridine (6038-59-1,55062-69-6) + 2'-O-methyluridine (2140-76-3)

Guidance literature:

With tin(ll) chloride; In N,N-dimethyl-formamide; at 50 ℃; Title compound not separated from byproducts;

upstream raw materials:

diazomethane

uridine

3'-O-methyl-5'-O-(monomethoxytrityl)uridine

C₂₅H₂₈N₂O₇

Refernces

• 1、 Cramer, Hagen,Pfleiderer, Wolfgang. "176. Nucleosides part LXI: A simple procedure for the monomethylation of protected and unprotected ribonucleosides in the 2′-O- and 3′-O-position using diazomethane and the catalyst stannous chloride". . p. 2114 - 2136. Retrieved 2007/10/03.
• 2、 Robins,Naik,Lee. "Nucleic acid related compounds. 12. The facile and high-yield stannous chloride catalyzed monomethylation of the cis-glycol system of nucleosides by diazomethane.". . p. 1891 - 1899. Retrieved 2007/10/05.