Technology Process of (25R)-3-keto-5α-cholest-7-en-26-oic acid
There total 12 articles about (25R)-3-keto-5α-cholest-7-en-26-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chromium(VI) oxide; sulfuric acid;
In
acetone;
at 0 ℃;
for 1h;
DOI:10.1055/s-2008-1077958
- Guidance literature:
-
(E)-3-oxo-5α-cholest-7,25-enoic acid;
In
methanol;
for 0.25h;
Inert atmosphere;
Schlenk technique;
With
bis(acetato){(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl}rutenium(II); hydrogen;
In
methanol;
at 50 ℃;
for 3.01667h;
diastereoselective reaction;
DOI:10.1002/anie.201307465
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C
1.2: 0 °C
2.1: 2-iodoxybenzoic acid; trifluoroacetic acid / dimethyl sulfoxide / 60 °C / Darkness
3.1: lithium; ammonia / tert-butyl alcohol; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.25 h / 20 °C
4.2: 20 °C
5.1: Burgess Reagent / toluene / Reflux
6.1: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C
7.1: methanol / 0.25 h / Inert atmosphere; Schlenk technique
7.2: 3.02 h / 50 °C
With
Burgess Reagent; 2-iodoxybenzoic acid; ammonia; lithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
5.1: |Burgess Alcohol Dehydration;
DOI:10.1002/anie.201307465
