14773-00-3 Usage
Description
3-Oxo-7α-hydroxy-5β-cholan-24-oic acid methyl ester is a steroidal compound characterized by its unique chemical structure and properties. It is a yellow solid with a molecular formula that reflects its steroidal nature and functional groups. 3-Oxo-7α-hydroxy-5β-cholan-24-oic acid methyl ester is derived from bile acids and has been found to possess various biological activities, making it a potential candidate for pharmaceutical and chemical applications.
Uses
Used in Pharmaceutical Industry:
3-Oxo-7α-hydroxy-5β-cholan-24-oic acid methyl ester is used as a bile acid transporter for the regulation of cholesterol and lipid metabolism. Its steroidal structure allows it to interact with specific transport proteins, making it a valuable compound for the development of drugs targeting cholesterol-related disorders.
Used in Chemical Research:
As a steroidal compound, 3-Oxo-7α-hydroxy-5β-cholan-24-oic acid methyl ester is used as a starting material or intermediate in the synthesis of various steroidal drugs and hormones. Its unique functional groups and structural features make it a versatile building block for the development of new pharmaceuticals with potential therapeutic applications.
Used in Drug Delivery Systems:
3-Oxo-7α-hydroxy-5β-cholan-24-oic acid methyl ester can be utilized in the development of targeted drug delivery systems, particularly for compounds that require transport across biological membranes. Its steroidal structure and bile acid transporter properties can be exploited to enhance the bioavailability and efficacy of various drugs, particularly those with poor membrane permeability.
Check Digit Verification of cas no
The CAS Registry Mumber 14773-00-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,7 and 3 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14773-00:
(7*1)+(6*4)+(5*7)+(4*7)+(3*3)+(2*0)+(1*0)=103
103 % 10 = 3
So 14773-00-3 is a valid CAS Registry Number.
14773-00-3Relevant articles and documents
Efficient and selective microwave Oppenauer oxidation of sterol derivatives
Négrel, Sophie,Brunel, Jean Michel
, (2021)
An improved, fast, and accurate procedure for regioselective microwave Oppenauer oxidation of sterol derivatives is reported leading to the expected corresponding ketosterols in moderate to excellent isolated yields ranging from 58 to 81%. The influence of different parameters dealing with the nature of the solvent and of the Lewis acid/ketone couple used, the reaction temperature as well as the hydrolysis conditions were also investigated on the outcome of the reaction.
METHOD AND COMPOSITIONS FOR FORMING A COPPER-CONTAINING COMPLEX AND USES THEREOF
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Paragraph 0134; 0135; 0156; 0164; 0165, (2019/05/22)
Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula (I): wherein R is -OH or -O-CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula (I). Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula (I) optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula (I).
A stereoselective synthesis of the allo-bile acids from the 5β-isomers
Li, Qingjiang,Tochtrop, Gregory P.
supporting information; experimental part, p. 4137 - 4139 (2011/09/19)
The allo-bile acids are a subset of the family of steroidal detergents found in most vertebrates. Because there are no major biological feedstocks for isolation of the allo-bile acids, they must be synthesized from the abundant 5β-reduced isomers. Here we report a general set of methods for the synthesis of allo-bile acids from the corresponding 5-β isomers demarcated by a selective C-3 oxidation, IBX unsaturation, and stereoselective saturation.
