1377666-88-0

Basic information

• Product Name: Δ^1,7-dafachronic acid
• Synonyms: Δ^1,7-dafachronic acid
• CAS NO: 1377666-88-0
• Molecular Weight: 412.613
• Mol File: 1377666-88-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Δ^1,7-dafachronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Δ^1,7-dafachronic acid(1377666-88-0)
• EPA Substance Registry System: Δ^1,7-dafachronic acid(1377666-88-0)

Safety Data

• Hazardous Substances Data: 1377666-88-0(Hazardous Substances Data)

Upstream product

• 14773-00-3 methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate 

Relevant articles and documents

A photocleavable masked nuclear-receptor ligand enables temporal control of C.elegans development

The development and lifespan of C.elegans are controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitaminD and liverX receptors. As with its mammalian homologues, DAF-12 function is regulated by bile acid-like steroidal ligands; however, tools for investigating their biosynthesis and function invivo are lacking. A flexible synthesis for DAF-12 ligands and masked ligand derivatives that enable precise temporal control of DAF-12 function was developed. For ligand masking, photocleavable amides of 5-methoxy-N-methyl-2-nitroaniline (MMNA) were introduced. MMNA-masked ligands are bioavailable and after incorporation into the worm, brief UV irradiation can be used to trigger the expression of DAF-12 target genes and initiate development from dauer larvae into adults. The invivo release of DAF-12 ligands and other small-molecule signals by using photocleavable MMNA-masked ligands will enable functional studies with precise spatial and temporal resolution. Copyright