949004-11-9Relevant articles and documents
Mixed bioengineering-chemical synthesis approach for the efficient preparation of δ7-dafachronic acid
Kinzurik, Matias I.,Hristov, Lachezar V.,Matsuda, Seiichi P. T.,Ball, Zachary T.
supporting information, p. 2188 - 2191 (2014/05/06)
Combining bioengineering with chemical synthesis has enabled an efficient method for producing δ7-dafachronic acid, a steroidal hormone associated with nematode germline longevity. Saccharomyces cerevisiae was engineered to produce 7,24-cholestadienol, a convenient starting material for a four-step synthesis of δ7-dafachronic acid.
Synthesis and biological activity of the (25R)-cholesten-26-oic acids - Ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans
Martin, Rene,Schmidt, Arndt W.,Theumer, Gabriele,Krause, Tilo,Entchev, Eugeni V.,Kurzchalia, Teymuras V.,Knoelker, Hans-Joachim
experimental part, p. 909 - 920 (2009/05/30)
We describe the stereoselective transformation of diosgenin (4a) to (25R)-Δ4-dafachronic acid (1a), (25R)-Δ7- dafachronic acid (2a), and (25R)-cholestenoic acid (3a), which represent potential ligands for the hormonal receptor DAF-12
An efficient, stereocontrolled synthesis of the 25-(R)-diastereomer of dafchronic acid A from β-ergosterol
Giroux, Simon,Corey
supporting information; experimental part, p. 801 - 802 (2009/04/07)
A direct and stereocontrolled synthesis of the 25-(R)-diastereomer of dafachronic acid A from β-ergosterol has been developed.
