Technology Process of {2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester
There total 3 articles about {2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
water; toluene;
for 16h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation; Inert atmosphere
2: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux
3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium carbonate / water; toluene / 16 h / Inert atmosphere; Reflux
With
hydrogenchloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tricyclohexylphosphine;
In
1,4-dioxane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux
2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium carbonate / water; toluene / 16 h / Inert atmosphere; Reflux
With
hydrogenchloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; water; toluene;