5-(4-Fluorophenyl)thiazol-2-amine

Base Information

• Chemical Name: 5-(4-Fluorophenyl)thiazol-2-amine
• CAS No.: 774-50-5
• Molecular Formula: C9H7FN2S
• Molecular Weight: 194.232
• European Community (EC) Number: 857-582-1
• DSSTox Substance ID: DTXSID30501277
• Nikkaji Number: J2.593.750C
• Wikidata: Q72476522
• Mol file: 774-50-5.mol

Synonyms:5-(4-Fluorophenyl)thiazol-2-amine;774-50-5;5-(4-fluorophenyl)-1,3-thiazol-2-amine;2-AMINO-5-(4-FLUOROPHENYL)-THIAZOLE;5-(4-FLUOROPHENYL)-2-THIAZOLAMINE;SCHEMBL4831643;DTXSID30501277;AKOS010254397;EN300-96081;E97746;Z732776460

Chemical Property of 5-(4-Fluorophenyl)thiazol-2-amine

Chemical Property:

• Boiling Point: 359.1 °C at 760 mmHg
• Flash Point: 171 °C
• PSA: 67.88000
• Density: 1.349 g/cm³
• LogP: 2.46150
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 194.03139757
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

5-(4-fluorophenyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CN=C(S2)N)F

Technology Process of 5-(4-Fluorophenyl)thiazol-2-amine

There total 3 articles about 5-(4-Fluorophenyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide (73040-69-4) → 5-(4-fluorophenyl)thiazol-2-ylamine (774-50-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 6h; Reflux;

Reference yield:

4-fluoro-1-iodobenzene (352-34-1) → 5-(4-fluorophenyl)thiazol-2-ylamine (774-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation; Inert atmosphere

2: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux

With hydrogenchloride; potassium phosphate; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

2,2-dichloro-1-(4-fluoro-phenyl)-ethanol (61693-75-2) + thiourea (17356-08-0) → 5-(4-fluorophenyl)thiazol-2-ylamine (774-50-5)

Guidance literature:

With potassium hydroxide; In methanol;

upstream raw materials:

2,2-dichloro-1-(4-fluoro-phenyl)-ethanol

thiourea

4-fluoro-1-iodobenzene

N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide

Downstream raw materials:

{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide

Refernces

• 1、 -. "NOVEL KINASE INHIBITORS". . . Retrieved 2014/05/07.