4-CHLORO-BENZAMIDINE

Base Information

• Chemical Name: 4-CHLORO-BENZAMIDINE
• CAS No.: 19563-04-3
• Molecular Formula: C7H7ClN2
• Molecular Weight: 154.599
• Hs Code.: 2925290090
• Mol file: 19563-04-3.mol

Synonyms:Benzamidine,p-chloro- (6CI,7CI,8CI);p-Chlorobenzamidine;p-Chlorophenylcarbodiimide;

Chemical Property of 4-CHLORO-BENZAMIDINE

Chemical Property:

• Boiling Point: 241.098 °C at 760 mmHg
• Flash Point: 99.613 °C
• PSA: 49.87000
• Density: 1.295 g/cm³
• LogP: 2.42410
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Chlorobenzene-1-carboximidamide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-BENZAMIDINE

There total 9 articles about 4-CHLORO-BENZAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

4-Cyanochlorobenzene (623-03-0) → p-chlorobenzamidine (19563-04-3)

Guidance literature:

4-Cyanochlorobenzene; With N-acetylcystein; In ethanol; at 45 ℃; for 20h;

With ammonium acetate; In ethanol; for 68h;

Reference yield: 70.0%

4-chloro-N-hydroxybenzimidamide (5033-28-3) → p-chlorobenzamidine (19563-04-3)

Guidance literature:

With platinum on carbon; ammonium formate; acetic acid; for 36h; Reflux; Inert atmosphere;

Reference yield:

benzenesulfonamide (98-10-2) + para-chlorobenzoic acid (74-11-3) → 4-Cyanochlorobenzene (623-03-0) + p-chlorobenzamidine (19563-04-3)

Guidance literature:

at 225 ℃;

upstream raw materials:

4-Cyanochlorobenzene

ammonium acetate

benzenesulfonamide

para-chlorobenzoic acid

Downstream raw materials:

2-p-chlorophenyl-4,6-dihydroxypyrimidine

C₂₄H₁₅ClN₂O

C₁₅H₁₀Cl₂N₂

2-(4-chlorophenyl )-4-(4-methoxyphenyl)-1H-imidazole

Refernces

• 1、 Lu, Xiaodong,Xin, Xiaoyi,Wan, Boshun. "Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide". . p. 361 - 364. Retrieved 2018/01/08.
• 2、 Bauch, Eva,Reichmann, Debora,Mendel, Ralf-Rainer,Bittner, Florian,Manke, Anne-Marie,Kurz, Philipp,Girreser, Ulrich,Havemeyer, Antje,Clement, Bernd. "Electrochemical and mARC-catalyzed enzymatic reduction of para-substituted benzamidoximes: Consequences for the prodrug concept "amidoximes instead of amidines"". . p. 360 - 367. Retrieved 2015/02/05.