FA-GLY-OH

Base Information

• Chemical Name: FA-GLY-OH
• CAS No.: 124882-74-2
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2932190090
• Mol file: 124882-74-2.mol

Synonyms:Glycine,N-[(2E)-3-(2-furanyl)-1-oxo-2-propenyl]- (9CI);Glycine, N-[3-(2-furanyl)-1-oxo-2-propenyl]-,(E)-;N-[(2E)-3-(furan-2-yl)prop-2-enoyl]glycine;glycine, N-[(2E)-3-(2-furanyl)-1-oxo-2-propen-1-yl]-;N-[(2E)-3-(2-furyl)prop-2-enoyl]glycine;

Chemical Property of FA-GLY-OH

Chemical Property:

• Vapor Pressure: 3.92E-10mmHg at 25°C
• Melting Point: 218-221 °C(lit.)
• Refractive Index: 1.58
• Boiling Point: 482.8 °C at 760 mmHg
• PKA: 3.60±0.10(Predicted)
• Flash Point: 245.8 °C
• PSA: 79.54000
• Density: 1.329 g/cm³
• LogP: 0.88450
• Storage Temp.: Store at RT.
• Solubility.: Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

FA-GLY-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FA-GLY-OH

There total 12 articles about FA-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Furanacryloylglycine methyl ester (73353-76-1) → N-<3-(2-furyl)acryloyl>-Gly (124882-74-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.11.082

Reference yield: 34.0%

(E)-1-(1H-1,2,3-benzotriazol-1-yl)-3-(2-furyl)-2-propen-1-one (519054-08-1) + glycine (56-40-6,18875-39-3,25718-94-9) → N-<3-(2-furyl)acryloyl>-Gly (124882-74-2)

Guidance literature:

With triethylamine; In 1,2-dimethoxyethane; water; at 20 ℃; for 48h;

DOI:10.3987/COM-08-S(F)109

Reference yield: 8.6%

GlyOEt*HCl (459-73-4) + 3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1) → N-<3-(2-furyl)acryloyl>-Gly (124882-74-2)

Guidance literature:

GlyOEt*HCl; 3-(fur-2-yl)crotonic acid; With dicyclohexyl-carbodiimide; In 1,4-dioxane; for 24h;

With sodium hydroxide; at 90 ℃; for 1h;

DOI:10.1016/0278-6915(94)90086-8

upstream raw materials:

N-(3-<2-furyl>acryloyl)-Gly-LeuNH2

N-<3-(2-furyl)acryloyl>-Gly-Leu-NH2

N-<3-(2-furyl)acryloyl>-Gly-Phe-NH2

(2S)-amino-4-methylpentanamide hydrochloride

Downstream raw materials:

glycine

N-<3-(2-furyl)acryloyl>-Gly-Leu-NH2

Refernces

• 1、 Fukuda, Mitsuhiro,Kunugi, Shigeru. "Mechanism of Dipeptidyl Carboxypeptidase Activity of Thermolysin". . p. 2965 - 2970. Retrieved 1984.
• 2、 Parkash, M. K.,Caldwell, J.. "METABOLISM AND EXCRETION OF FURFURAL IN THE RAT AND MOUSE". . p. 887 - 896. Retrieved 1994.
• 3、 Michel Brunel, Jean,Salmi, Chanaz,Letourneux, Yves. "Efficient peptide coupling method of conjugated carboxylic acids with methyl ester amino acids hydrochloride. Application to the synthesis of Fa-Met, an important enzymatic substrate". . p. 217 - 220. Retrieved 2007/10/03.