N-(2-Furfurylideneacetyl)glycine methyl ester

Base Information

• Chemical Name: N-(2-Furfurylideneacetyl)glycine methyl ester
• CAS No.: 73353-76-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID70420998
• Nikkaji Number: J2.130.588J
• Wikidata: Q82232332
• Mol file: 73353-76-1.mol

Synonyms:N-(2-Furfurylideneacetyl)glycine methyl ester;73353-76-1;methyl 2-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]acetate;SCHEMBL18301499;DTXSID70420998;AKOS008933786;Methyl 2-(3-(furan-2-yl)acrylamido)acetate;N-[3-(2-Furanyl)acryloyl]glycine methyl ester;N-(2-Furfurylideneacetyl)glycine methyl ester, 98%;methyl 2-[(2E)-3-(furan-2-yl)prop-2-enamido]acetate

Chemical Property of N-(2-Furfurylideneacetyl)glycine methyl ester

Chemical Property:

• Vapor Pressure: 1.17E-06mmHg at 25°C
• Melting Point: 133-136 °C(lit.)
• Refractive Index: 1.536
• Boiling Point: 401.5°C at 760 mmHg
• Flash Point: 196.6°C
• PSA: 72.03000
• Density: 1.215g/cm³
• LogP: 1.42230
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 209.06880783
• Heavy Atom Count: 15
• Complexity: 262

Purity/Quality:

99% ^*data from raw suppliers

N-(2-FURFURYLIDENEACETYL)GLYCINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CNC(=O)C=CC1=CC=CO1
• Isomeric SMILES: COC(=O)CNC(=O)/C=C/C1=CC=CO1

Technology Process of N-(2-Furfurylideneacetyl)glycine methyl ester

There total 1 articles about N-(2-Furfurylideneacetyl)glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1) → Furanacryloylglycine methyl ester (73353-76-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.11.082

Reference yield: 84.0%

Furanacryloylglycine methyl ester (73353-76-1) → N-<3-(2-furyl)acryloyl>-Gly (124882-74-2)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.11.082

upstream raw materials:

glycine ethyl ester hydrochloride

3-(fur-2-yl)crotonic acid

Downstream raw materials:

N-<3-(2-furyl)acryloyl>-Gly

Refernces