2,3-Diaminophenol

Base Information

• Chemical Name: 2,3-Diaminophenol
• CAS No.: 59649-56-8
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 29222990
• Mol file: 59649-56-8.mol

Synonyms:2,3-Diaminophenol;3-Hydroxy-1,2-diaminobenzene;3-Hydroxy-1,2-phenylenediamine;3-Hydroxy-o-phenylenediamine;AC1LBBSB;AC1Q7AKD;AR-1D2346;CID579937;

Chemical Property of 2,3-Diaminophenol

Chemical Property:

• Appearance/Colour: White to beige crystalline powder
• Vapor Pressure: 0.000513mmHg at 25°C
• Melting Point: 161-165 °C
• Refractive Index: 1.722
• Boiling Point: 303.6 °C at 760 mmHg
• PKA: 9.81±0.10(Predicted)
• Flash Point: 137.4 °C
• PSA: 72.27000
• Density: 1.343 g/cm³
• LogP: 1.71900
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3-Diaminophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-Diaminophenol was used:in one-pot microwave assisted synthesis of amino-1,5-benzoxazepines and hydroxyl-1,5-benzodiazepines in the electrosynthesis of poly(2,3-diaminophenol) via electro-oxidation in a synthesis of tetradentate Schiff base complexes via reaction with salicylaldehyde or 5-bromosalicylaldehyde and metals such as Mn(III), Ni(II) and Cu(II)

Technology Process of 2,3-Diaminophenol

There total 6 articles about 2,3-Diaminophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Amino-3-nitrophenol (603-85-0) → 2,3-diaminophenol (59649-56-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.7b01691

Reference yield: 91.0%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + BPA (80-05-7) + HO-R1-OH + dichlorotriphenylphosphorane (2526-64-9) → 2,3-diaminophenol (59649-56-8)

Guidance literature:

In methanol;

Reference yield:

2,3-dinitrophenol (66-56-8) → 2,3-diaminophenol (59649-56-8)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation;

DOI:10.1021/jo01143a016

upstream raw materials:

2,3-dinitrophenol

2-Amino-3-nitrophenol

benzo[1,2,5]thiadiazol-4-ol

ethanol

Downstream raw materials:

C₂HF₃O₂*C₁₇H₁₅N₃O₃

4-hydroxy-1,3-dihydro-benzoimidazol-2-one

2-(5-nitrofuran-2-yl)-3H-benzo[d]imidazol-4-ol

5-hydroxy-1H-quinoxalin-2-one

Refernces

• 1、 Zhang, Huijun,Fang, Xiong,Meng, Qian,Mao, Yujia,Xu, Yan,Fan, Tingting,An, Jing,Huang, Ziwei. "Design, synthesis and characterization of potent microtubule inhibitors with dual anti-proliferative and anti-angiogenic activities". supporting information. p. 380 - 396. Retrieved 2018/08/17.
• 2、 Rewcastle, Gordon W.,Gamage, Swarna A.,Flanagan, Jack U.,Frederick, Raphael,Denny, William A.,Baguley, Bruce C.,Kestell, Philip,Singh, Ripudaman,Kendall, Jackie D.,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Buchanan, Christina M.,Jamieson, Stephen M. F.,Shepherd, Peter R.. "Synthesis and biological evaluation of novel analogues of the pan class i phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)". experimental part. p. 7105 - 7126. Retrieved 2011/12/04.