o-bromo-N-hydroxybenzamide

Base Information

• Chemical Name: o-bromo-N-hydroxybenzamide
• CAS No.: 2593-27-3
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.034
• Mol file: 2593-27-3.mol

Synonyms:o-bromo-N-hydroxybenzamide

Chemical Property of o-bromo-N-hydroxybenzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-bromo-N-hydroxybenzamide

There total 6 articles about o-bromo-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-bromobenzoic acid chloride (7154-66-7) → o-bromo-N-hydroxybenzamide (2593-27-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.0833333h;

Reference yield: 82.0%

2-bromobenzoic acid methyl ester (610-94-6) → o-bromo-N-hydroxybenzamide (2593-27-3)

Guidance literature:

With hydroxylamine hydrochloride; potassium hydroxide; In methanol; for 24h; Reflux;

DOI:10.1002/adsc.201200760

Reference yield: 42.0%

2-bromobenzoic-acid (88-65-3) → o-bromo-N-hydroxybenzamide (2593-27-3)

Guidance literature:

2-bromobenzoic-acid; With 1,1'-carbonyldiimidazole; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

With dmap; O-Trimethylsilylhydroxylamine; In dimethyl sulfoxide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.10.037

upstream raw materials:

2-bromobenzoic acid methyl ester

2-bromobenzoic acid ethyl ester

2-bromobenzaldehyde oxime

2-bromobenzoic acid chloride

Downstream raw materials:

2-bromoaniline

N-(2-bromophenyl)formamide

5-chloro-2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one

Refernces

• 1、 Zuo, Youpeng,He, Xinwei,Tang, Qiang,Hu, Wangcheng,Zhou, Tongtong,Hu, Wenbo,Shang, Yongjia. "Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones". supporting information. p. 2117 - 2123. Retrieved 2020/12/22.
• 2、 Huang, Xiu-Rong,Zhang, Yu-Mei,Wan, Ting-Biao,Zhang, Piao,Zhang, Xiu-Xiu,Wang, Fang-Ming,Xu, Defeng,Shen, Mei-Hua,Xu, Hua-Dong. "Straightforward synthesis of 4,5-bifunctionalized 1,2-oxazinanes via Lewis acid promoted regio- and stereo-selective nucleophilic ring-opening of 3,6-dihydro-1,2-oxazine oxides". supporting information. . Retrieved 2019/10/19.