(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

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Chemical Name:(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate
CAS No.:1075726-76-9
Molecular Formula:C₂H₂O₄*C₂₄H₃₁NO₆
Molecular Weight:519.549
Hs Code.:
Mol file:1075726-76-9.mol

Synonyms:(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

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Chemical Property of (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate Edit

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Technology Process of (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

There total 2 articles about (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3395-91-3
Methyl 3-bromopropionate

: 141109-12-8
(R)-tetrahydropapaverine N-acetyl-L-leucine salt

: 144-62-7,97993-78-7
oxalic acid

: 1075726-76-9
(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

Guidance literature:: Methyl 3-bromopropionate; (R)-tetrahydropapaverine N-acetyl-L-leucine salt; With sodium carbonate; In water; toluene; acetonitrile; at 55 - 80 ℃; for 24h; pH=9;

oxalic acid; In acetone; Temperature; Reagent/catalyst; pH-value;

Reference yield: 85.0%

: 144-62-7,97993-78-7
oxalic acid

: 54417-53-7,66820-84-6
(R)-tetrahydropapaverine hydrochloride

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1075726-76-9
(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

Guidance literature:: (R)-tetrahydropapaverine hydrochloride; With ammonium hydroxide; In dichloromethane; water; at 25 ℃; for 0.25h; pH=9 - 10;

acrylic acid methyl ester; With acetic acid; In benzene; at 80 ℃; for 4h;

oxalic acid; In ethyl acetate; acetone; benzene; at 25 ℃; for 0.25h;

Reference yield: 48.5%

: 1075726-76-9
(1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate

: 80-18-2
Methyl benzenesulfonate

: 1075726-88-3
(1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-methoxycarbonylethyl-isoquinolinium besylate

Guidance literature:: (1R)-1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methoxycarbonylethyl-isoquinoline oxalate; With sodium hydroxide; In water; toluene; at 25 ℃; for 0.25h; pH=9 - 10;

Methyl benzenesulfonate; In acetonitrile; at 30 ℃; for 20h;