MIANSERIN-D3

Base Information

• Chemical Name: MIANSERIN-D3
• CAS No.: 81957-76-8
• Molecular Formula: C₁₈H₂₀N₂
• Molecular Weight: 267.346
• Mol file: 81957-76-8.mol

Synonyms:(+/-)-Mianserin-d3 Hydrochloride;mianserin;1,2,3,4,10,14b-Hexahydro-2-(methyl-d3)-dibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride;(+/-)-Mianserin;Mianserine-d3 Dihydrochloride;

Chemical Property of MIANSERIN-D3

Chemical Property:

• Flash Point: 9℃
• PSA: 6.48000
• LogP: 3.08680
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Mianserin-D3 solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MIANSERIN-D3

There total 4 articles about MIANSERIN-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

1,2,3,4,10,14b-hexahydrodibenzo[c,f]-pyrazino[1,2-a]azepine (71936-92-0,136315-25-8) → mianserin (81957-76-8)

Guidance literature:

With iodomethane-d3; sodium hydrogencarbonate; In methanol; at 30 ℃; for 3h;

DOI:10.1021/jo00329a043

Reference yield:

N-Cyanomianserin (119200-54-3) → mianserin (81957-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / Zn / H₂O; acetic acid / 3 h / 60 °C

2: 31 percent / C⁽²⁾H₃I; NaHCO₃ / methanol / 3 h / 30 °C

With iodomethane-d3; sodium hydrogencarbonate; zinc; In methanol; water; acetic acid;

DOI:10.1021/jo00329a043

Reference yield:

mianserin (24219-97-4) → mianserin (81957-76-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / CHCl₃ / 2 h / 60 °C

2: 30 percent / Zn / H₂O; acetic acid / 3 h / 60 °C

3: 31 percent / C⁽²⁾H₃I; NaHCO₃ / methanol / 3 h / 30 °C

With iodomethane-d3; sodium hydrogencarbonate; zinc; In methanol; chloroform; water; acetic acid;

DOI:10.1021/jo00329a043

upstream raw materials:

iodomethane-d3

1,2,3,4,10,14b-hexahydrodibenzo[c,f]-pyrazino[1,2-a]azepine

N-Cyanomianserin

mianserin

Refernces

• 1、 Filer,Fazio,Ahern. "(±)-[methyl-3H and -2H]mianserin. Participants in a dramatic instance of HPLC isotopic fractionation". . p. 3344 - 3346. Retrieved 2007/10/02.