5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE

Base Information

• Chemical Name: 5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE
• CAS No.: 742099-65-6
• Molecular Formula: C11H12BrNO2
• Molecular Weight: 270.126
• Hs Code.: 2934999090
• Mol file: 742099-65-6.mol

Synonyms:5-Bromo-2-(n-morpholino)-benzaldehyde;

Chemical Property of 5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 401.7 °C at 760 mmHg
• Flash Point: 196.7 °C
• PSA: 29.54000
• Density: 1.495 g/cm³
• LogP: 2.16320

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-(N-morpholino)-benzaldehyde 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE

There total 1 articles about 5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 5-bromo-2-fluorobenzaldehyde (93777-26-5) → 5-bromo-2-(morpholin-4-yl)benzaldehyde (742099-65-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

DOI:10.1016/j.bmcl.2018.02.055

Reference yield: 85.0%

5-bromo-2-(morpholin-4-yl)benzaldehyde (742099-65-6) + bis(pinacol)diborane (73183-34-3) → 2-morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In toluene; at 95 ℃; for 3h; Inert atmosphere;

Reference yield: 79.0%

5-bromo-2-(morpholin-4-yl)benzaldehyde (742099-65-6) → 4-bromophenyl-morpholine (30483-75-1)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at 20 ℃; for 6h; Irradiation; Inert atmosphere; Green chemistry;

DOI:10.1039/d0gc01256d

upstream raw materials:

morpholine

5-bromo-2-fluorobenzaldehyde

Downstream raw materials:

ethyl (2E)-3-(5-bromo-2-morpholin-4-ylphenyl)acrylate

Refernces

• 1、 Li, Lamei,Wang, Songping,Wei, Wentao,Yan, Ming,Zhou, Jingwei. "Catalyst-free photodecarbonylation ofortho-amino benzaldehyde". supporting information. p. 3421 - 3426. Retrieved 2020/06/25.
• 2、 -. "ACRYLAMIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE". Page/Page column 74. . Retrieved 2010/02/14.