2-(4-Methoxyphenyl)thiophene

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)thiophene
• CAS No.: 42545-43-7
• Molecular Formula: C11H10OS
• Molecular Weight: 190.266
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70377731
• Nikkaji Number: J876.159K
• Wikidata: Q82167062
• Mol file: 42545-43-7.mol

Synonyms:2-(4-methoxyphenyl)thiophene;42545-43-7;Thiophene,2-(4-methoxyphenyl)-;HMS563G21;Maybridge1_007721;2-paramethoxyphenylthiophene;SCHEMBL23951;2-(4-methoxy-phenyl)-thiophene;DTXSID70377731;TWKDIVDAGCWHES-UHFFFAOYSA-N;GEO-01709;MFCD00204185;AKOS004114004;GS-0664;BB 0222681;CS-0364610;FT-0608668;E89432;A825936;W-200365

Chemical Property of 2-(4-Methoxyphenyl)thiophene

Chemical Property:

• Vapor Pressure: 0.00254mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 296.4 °C at 760 mmHg
• Flash Point: 133.1 °C
• PSA: 37.47000
• Density: 1.131 g/cm³
• LogP: 3.42370
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.04523611
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxyphenyl)thiophene 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC=CS2

Technology Process of 2-(4-Methoxyphenyl)thiophene

There total 138 articles about 2-(4-Methoxyphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromothiophene (1003-09-4) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 2-(4-methoxyphenyl)thiophene (42545-43-7) + 4,4'-Dimethoxybiphenyl (2132-80-1) + 2,2'-Bithiophene (492-97-7)

Guidance literature:

4-methoxyphenyl magnesium bromide; With bismuth(III) chloride;

2-bromothiophene; With potassium phosphate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0030-1260554

Reference yield: 72.0%

p-methoxyphenyl(phenyl)iodonium tetrafluoroborate (733-53-9) + 2-thienyllead(IV) triacetate (53034-24-5) → 2-(4-methoxyphenyl)thiophene (42545-43-7) + 2,2'-Bithiophene (492-97-7)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium methylate; In chloroform; for 3h; Ambient temperature;

DOI:10.1080/00397919908086256

Reference yield: 65.0%

thiophen-2-yl magnesium bromide (5713-61-1) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 2-(4-methoxyphenyl)thiophene (42545-43-7) + 4,4'-Dimethoxybiphenyl (2132-80-1) + 2,2'-Bithiophene (492-97-7)

Guidance literature:

With oxygen; lithium chloride; manganese(ll) chloride; In tetrahydrofuran; at -5 - 0 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.200902188

upstream raw materials:

thiophene

1-bromo-4-methoxy-benzene

para-iodoanisole

2-thienylzinc chloride

Downstream raw materials:

2-(2-(5-(4-methoxyphenyl)thiophen-2-yl)phenyl)pyridine

10-(5-(4-methoxyphenyl)thiophen-2-yl)benzo[h]quinoline

2-formyl-5-(4-methoxyphenyl)thiophene

5-(4-methoxylphenyl)-2-bromothiophene

Refernces

• 1、 Chaubey, Surabhi,Yadav, Rajesh K.,Kim, Tae Wu,Yadav, Tara Chand,Kumar, Abhishek,Dwivedi,Pandey,Singh, Atul P.. "Fabrication of Graphitic Carbon Nitride-Based Film: An Emerged Highly Efficient Catalyst for Direct C—H Arylation under Solar Light". . p. 633 - 639. Retrieved 2021/02/12.
• 2、 Kang, Qi-Kai,Li, Ke,Li, Yuntong,Lin, Yunzhi,Shi, Hang,Xu, Lun. "Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides". supporting information. p. 20391 - 20399. Retrieved 2021/08/13.