4-ETHOXY-3-FLUOROBENZALDEHYDE

Base Information

• Chemical Name: 4-ETHOXY-3-FLUOROBENZALDEHYDE
• CAS No.: 452-00-6
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 2913000090
• Mol file: 452-00-6.mol

Synonyms:4-Ethoxy-3-fluorobenzaldehyde;

Chemical Property of 4-ETHOXY-3-FLUOROBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 262.403 °C at 760 mmHg
• Flash Point: 109.161 °C
• PSA: 26.30000
• Density: 1.153 g/cm³
• LogP: 2.03690
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-ethoxy-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ETHOXY-3-FLUOROBENZALDEHYDE

There total 4 articles about 4-ETHOXY-3-FLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-fluoro-4-hydroxybenzaldehyde (405-05-0) + ethyl iodide (75-03-6) → 4-ethoxy-3-fluoro-benzaldehyde (452-00-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 18h;

Reference yield:

3-Fluor-4-aethoxy-α-chlortoluol (5749-33-7) → 4-ethoxy-3-fluoro-benzaldehyde (452-00-6)

Guidance literature:

With hexamethylenetetramine; In chloroform;

Reference yield:

1-ethoxy-2-fluoro-benzene (451-80-9) → 4-ethoxy-3-fluoro-benzaldehyde (452-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl, ZnCl₂ / H₂O

2: hexamethylenetetramine / CHCl₃ / Heating

With hydrogenchloride; hexamethylenetetramine; zinc(II) chloride; In chloroform; water;

upstream raw materials:

3-Fluor-4-aethoxy-α-chlortoluol

1-ethoxy-2-fluoro-benzene

3-fluoro-4-hydroxybenzaldehyde

ethyl iodide

Downstream raw materials:

1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole

(+/-)-4-Aethoxy-3-fluor-benzoesaeure-<2-diaethylamino-1-methyl-aethylester>

4-Aethoxy-3-fluorbenzoesaeure-<3-dibutylamino-propylester>

Refernces

• 1、 -. "Novel imidazole derivatives with anti-inflammatory activity". . . Retrieved 2008/06/13.