Technology Process of 5-bromo-3-[2-(3,5-dimethoxyphenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridinecarboxamide
There total 6 articles about 5-bromo-3-[2-(3,5-dimethoxyphenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridinecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-N-(tert-butyl)-3-methylpicolinamide;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
3,5-dimethoxybenzylchloride;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 3h;
DOI:10.1021/jo9803378
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 57 percent / tetrabutylammonium nitrate; TFAA; t-butyl methyl ether / 60 h / 20 °C
2.1: 85 percent / Fe; CaCl2 / aq. ethanol / 18 h / 20 °C
3.1: NaNO2; 48 percent HBr / H2O / 1 h / 0 °C
3.2: 78 percent / Cu / 0.5 h / Heating
4.1: 84 percent / H2SO4 / 1 h / 70 °C
5.1: LDA / tetrahydrofuran; hexane / -78 - 20 °C
With
tert-butyl methyl ether; sulfuric acid; hydrogen bromide; tetrabutylammonium nitrate; iron; trifluoroacetic anhydride; calcium chloride; lithium diisopropyl amide; sodium nitrite;
In
tetrahydrofuran; ethanol; hexane; water;
1.1: Nitration / 2.1: Reduction / 3.1: Diazotization / 3.2: Substitution / 4.1: Addition / 5.1: Alkylation;
DOI:10.1016/S0968-0896(99)00103-0