diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate

Base Information

• Chemical Name: diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate
• CAS No.: 1093490-31-3
• Molecular Formula: C₁₈H₂₁F₂O₄P
• Molecular Weight: 370.333
• Mol file: 1093490-31-3.mol

Synonyms:diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate

Chemical Property of diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate

There total 1 articles about diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

benzophenone (119-61-9) + Diethyl difluoromethylphosphonate (1478-53-1) → diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate (1093490-31-3)

Guidance literature:

Diethyl difluoromethylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -74 ℃; for 0.5h; Inert atmosphere;

benzophenone; In tetrahydrofuran; cyclohexane; at -74 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.006

Reference yield: 96.0%

diethyl 1,1-difluoro-2-hydroxy-2,2-diphenylethylphosphonate (1093490-31-3) → 1,1-Difluoro-2-hydroxy-2,2-diphenylethane (337-53-1)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.006

upstream raw materials:

benzophenone

Diethyl difluoromethylphosphonate

Downstream raw materials:

1,1-Difluoro-2-hydroxy-2,2-diphenylethane

Refernces