acetoxy-dideuterio-phenyl-methane

Base Information

• Chemical Name: acetoxy-dideuterio-phenyl-methane
• CAS No.: 50848-70-9
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 152.161
• Mol file: 50848-70-9.mol

Synonyms:acetoxy-dideuterio-phenyl-methane

Chemical Property of acetoxy-dideuterio-phenyl-methane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of acetoxy-dideuterio-phenyl-methane

There total 7 articles about acetoxy-dideuterio-phenyl-methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,1-dideuteriophenylmethanol (21175-64-4) + acetyl chloride (75-36-5) → acetoxy-dideuterio-phenyl-methane (50848-70-9)

Guidance literature:

1,1-dideuteriophenylmethanol; In toluene; at 110 ℃; for 20h;

acetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/d0sc03858j

Reference yield:

acetic anhydride (108-24-7) + C15H13(2)H2NO2S → 2-methyl-1,2-benzisothiazole-3(2H)-one (2527-66-4) + acetoxy-dideuterio-phenyl-methane (50848-70-9)

Guidance literature:

With sulfuric acid; at 80 ℃; for 2h; Mechanism;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → acetoxy-dideuterio-phenyl-methane (50848-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃, D₂O / Raney Co-Al / 2 h / 90 °C

2: AcONa / CH₂Cl₂ / 0.5 h

With water-d2; sodium acetate; sodium carbonate; Raney Co-Al; In dichloromethane;

upstream raw materials:

1,1-dideuteriobenzylamine

acetic anhydride

acetic acid

1,1-dideuteriophenylmethanol

Refernces

• 1、 Chia, C.S. Brian,Taylor, Mark S.,Dua, Suresh,Blanksby, Stephen J.,Bowie, John H.. "The collision induced loss of carbon monoxide from deprotonated benzyl benzoate in the gas phase. an anionic 1,2-Wittig type rearrangement". . p. 1435 - 1441. Retrieved 2007/10/03.
• 2、 Uchida, Yuzuru,Oae, Shigeru. "REACTIONS OF o-(N-METHYLCARBAMOYL)PHENYL SULPHOXIDES WITH ELECTROPHILES". . p. 649 - 654. Retrieved 2007/10/02.