2-Piperidin-1-ylmethyl-aniline

Base Information

• Chemical Name: 2-Piperidin-1-ylmethyl-aniline
• CAS No.: 19577-83-4
• Molecular Formula: C12H18N2
• Molecular Weight: 190.288
• Hs Code.: 2933399090
• Mol file: 19577-83-4.mol

Synonyms:2-Piperidin-1-ylmethyl-phenylamine;2-(Piperidin-1-ylmethyl)aniline;

Chemical Property of 2-Piperidin-1-ylmethyl-aniline

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 308.943 °C at 760 mmHg
• Flash Point: 126.501 °C
• PSA: 29.26000
• Density: 1.068 g/cm³
• LogP: 2.77380

Purity/Quality:

99% ^*data from raw suppliers

2-(Piperidin-1-ylmethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Piperidin-1-ylmethyl-aniline

There total 7 articles about 2-Piperidin-1-ylmethyl-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

piperidine (110-89-4) + 2-nitro-benzaldehyde (552-89-6) → 2-(piperidin-1-ylmethyl)aniline (19577-83-4)

Guidance literature:

With iron pentacarbonyl; In tetrahydrofuran; at 120 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.0c00794

Reference yield: 62.0%

piperidine (110-89-4) + 2-nitro-benzaldehyde (552-89-6) → 2-(piperidin-1-ylmethyl)aniline (19577-83-4) + 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline (5516-83-6)

Guidance literature:

With iron pentacarbonyl; at -30 - 25 ℃; for 36h; Schlenk technique; Cooling with liquid nitrogen;

DOI:10.1021/acs.joc.0c00794

Reference yield:

1-[(2-nitrophenyl)methyl]piperidine (50591-66-7) → 2-(piperidin-1-ylmethyl)aniline (19577-83-4)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2018.03.016

upstream raw materials:

1-[(2-nitrophenyl)methyl]piperidine

2-nitro-benzaldehyde

piperidine

Downstream raw materials:

8-piperidinomethyl-quinoline

Refernces

• 1、 Gay, Marion,Carato, Pascal,Coevoet, Mathilde,Renault, Nicolas,Larchanché, Paul-Emmanuel,Barczyk, Amélie,Yous, Sa?d,Buée, Luc,Sergeant, Nicolas,Melnyk, Patricia. "New phenylaniline derivatives as modulators of amyloid protein precursor metabolism". . p. 2151 - 2164. Retrieved 2018/03/23.