D-P-METHYL SULFONE PHENYL ETHYL SERINATE

Base Information

• Chemical Name: D-P-METHYL SULFONE PHENYL ETHYL SERINATE
• CAS No.: 36983-12-7
• Molecular Formula: C12H17NO5S
• Molecular Weight: 287.337
• Hs Code.: 2924299090
• Mol file: 36983-12-7.mol

Synonyms:D-Phenylalanine,b-hydroxy-4-(methylsulfonyl)-,ethyl ester, threo-;D-Phenylalanine, b-hydroxy-4-(methylsulfonyl)-, ethyl ester, (S)-;D-threo-b-Methylsulfonylphenylserine ethylester;

Chemical Property of D-P-METHYL SULFONE PHENYL ETHYL SERINATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 135-137°C
• Refractive Index: 1.554
• Boiling Point: 514.95 °C at 760 mmHg
• PKA: 10.57±0.45(Predicted)
• Flash Point: 265.233 °C
• PSA: 115.07000
• Density: 1.31g/cm³
• LogP: 1.79500
• Storage Temp.: Refrigerator
• Solubility.: Chloroform

Purity/Quality:

99% ^*data from raw suppliers

D-p-MethylSulfonePhenylEthylSerinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Florfenicol intermediate Florfenicol intermediate.

Technology Process of D-P-METHYL SULFONE PHENYL ETHYL SERINATE

There total 8 articles about D-P-METHYL SULFONE PHENYL ETHYL SERINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

para-methanesulfonylbenzaldehyde (5398-77-6) + glycine ethyl ester hydrochloride (623-33-6) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

With copper (II) carbonate hydroxide; ammonium hydroxide; potassium hydroxide; In ethanol; at 78 - 82 ℃; pH=10.5 - 11; Temperature; Reflux;

Reference yield: 97.0%

ethanol (64-17-5) + C10H12NO5S(1-)*0.5Cu(2+) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

With diethyl sulfate; at 20 ℃; Reagent/catalyst; Reflux;

Reference yield: 42.3%

ethanol (64-17-5) + para-methanesulfonylbenzaldehyde (5398-77-6) + glycine (56-40-6,18875-39-3,25718-94-9) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

para-methanesulfonylbenzaldehyde; glycine; With ammonium hydroxide; copper(II) sulfate; In water; at 50 ℃; for 22h; pH=9;

ethanol; With sulfuric acid; for 2.5h; Temperature; Reflux;

upstream raw materials:

ethanol

para-methanesulfonylbenzaldehyde

glycine ethyl ester hydrochloride

glycine

Downstream raw materials:

para-methanesulfonylbenzaldehyde

p-methylsulfonylbenzyl alcohol

(2S,3R)-2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid ethyl ester

thiamphenicol

Refernces

• 1、 -. "DL-p-methylsulfonylphenyl serine ethyl ester preparation method". Paragraph 0020-0038. . Retrieved 2020/02/29.
• 2、 -. "P-Methyl sulfone phenyl ethyl serinate and synthetic method thereof". Paragraph 0017; 0040; 0045-0059. . Retrieved 2018/09/12.