2-Ethoxyacetohydrazide

Base Information

• Chemical Name: 2-Ethoxyacetohydrazide
• CAS No.: 39242-95-0
• Molecular Formula: C4H10N2O2
• Molecular Weight: 118.136
• Hs Code.: 2928000090
• European Community (EC) Number: 831-728-4
• DSSTox Substance ID: DTXSID50563615
• Wikidata: Q82448092
• Mol file: 39242-95-0.mol

Synonyms:2-ethoxyacetohydrazide;39242-95-0;ethoxyacetic acid hydrazide;ETHOXYACETICACIDHYDRAZIDE;SCHEMBL2828605;SCHEMBL21027818;DTXSID50563615;NBPLLPBYZXYAMN-UHFFFAOYSA-N;AKOS000319528;AT27026;SB86083;CS-0259344;EN300-73041;A912820

Chemical Property of 2-Ethoxyacetohydrazide

Chemical Property:

• Vapor Pressure: 0.00755mmHg at 25°C
• Refractive Index: 1.446
• Boiling Point: 268.8 °C at 760 mmHg
• PKA: 12.40±0.18(Predicted)
• Flash Point: 116.3 °C
• PSA: 64.35000
• Density: 1.068 g/cm³
• LogP: 0.10400
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 118.074227566
• Heavy Atom Count: 8
• Complexity: 74.4

Purity/Quality:

98%Min ^*data from raw suppliers

2-Ethoxyacetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCC(=O)NN

Technology Process of 2-Ethoxyacetohydrazide

There total 1 articles about 2-Ethoxyacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-ethoxyethanoate (817-95-8) → 2-ethoxyacetylhydrazine (39242-95-0)

Guidance literature:

With hydrazine hydrate;

Reference yield: 76.0%

2-ethoxyacetylhydrazine (39242-95-0) + methyl (E)-3-(3-chloro-5-fluoro-1H-indol-1-yl)-N-(6-methoxypyridin-3-yl)azetidine-1-carbimidothioate → 3-chloro-1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)azeti din-3-yl)-5-fluoro-1H-indole

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 70 ℃; for 3h;

Reference yield: 62.2%

2-ethoxyacetylhydrazine (39242-95-0) + methyl (E)-3-(5-fluoro-3-methyl-1H-indol-1 -yl)-N-(6-methoxypyridin-3-yl)azetidine-1-carbimidothioate → 1-(1-(5-(ethoxymethyl)-4-(6-methoxypyridin-3-yl)-4H-1,2,4-triazol-3-yl)azetidin-3-yl)-5-fluoro-3-methyl-1H-indole

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 70 ℃; for 3h;

upstream raw materials:

ethyl 2-ethoxyethanoate

Downstream raw materials:

ethoxy-acetyl azide