4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline

Base Information

• Chemical Name: 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline
• CAS No.: 1360546-71-9
• Molecular Formula: C₁₇H₁₁BrN₂
• Molecular Weight: 323.192
• Mol file: 1360546-71-9.mol

Synonyms:4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline

Chemical Property of 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline

There total 15 articles about 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(1H-pyrrol-1-yl)aniline (6025-60-1) + 4-bromo-benzaldehyde (1122-91-4) → 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline (1360546-71-9)

Guidance literature:

With 1,2,3-Benzotriazole; aluminum (III) chloride; In tetrahydrofuran; at 25 ℃; under air;

DOI:10.1002/ejoc.201101013

Reference yield: 93.0%

1-(2-nitrophenyl)-1H-pyrrole (33265-60-0) + 4-bromobenzenemethanol (873-75-6) → 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline (1360546-71-9)

Guidance literature:

With trimethylamine-N-oxide; cyclopentyl methyl ether; oxygen; C₁₁H₁₂FeO₄Si; at 160 ℃; for 40h; Molecular sieve; Sealed tube;

DOI:10.1021/acs.joc.0c02145

Reference yield: 87.0%

1-(2-nitrophenyl)-1H-pyrrole (33265-60-0) + 4-Bromobenzylamine (3959-07-7) → 4-(4-bromophenyl)pyrrolo[1,2-a]quinoxaline (1360546-71-9)

Guidance literature:

With water; pyrographite; at 140 ℃; for 20h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.cclet.2019.04.007

upstream raw materials:

2-(1H-pyrrol-1-yl)aniline

4-bromo-benzaldehyde

1,4-bromoiodobenzene

1-[2-isocyanophenyl]-1H-pyrrole

Downstream raw materials:

4-(4’-methoxybiphenyl-4-yl)pyrrolo[1,2-a]quinoxaline

4-(4′-(methylthio)biphenyl-4-yl)pyrrolo[1,2-a]quinoxaline

methyl (E)-3-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]acrylate

ethyl (E)-3-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]acrylate

Refernces

• 1、 Bejarano, Oscar Rodríguez,Ochoa-Puentes, Cristian,Pe?a-Solórzano, Diana,Trujillo, Sergio Alfonso. "Tin(ii) chloride dihydrate/choline chloride deep eutectic solvent: Redox properties in the fast synthesis of: N -arylacetamides and indolo(pyrrolo)[1,2- a] quinoxalines". . p. 40552 - 40561. Retrieved 2020/11/18.
• 2、 Chun, Simin,Ahn, Jiwon,Putta, Ramachandra Reddy,Lee, Seok Beom,Oh, Dong-Chan,Hong, Suckchang. "Direct Synthesis of Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Transfer Hydrogenation between 1-(2-Nitrophenyl)pyrroles and Alcohols". . p. 15314 - 15324. Retrieved 2020/11/13.